Literature DB >> 25875212

Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

Robert Erdmann1, Cansu Ozden2, Jens Weidmann1, Alexander Schultze1.   

Abstract

Published recently in the Journal of Pathology, Lavoz et al. show that Gremlin promotes renal inflammation directly via VEGFR2. As Gremlin has been implicated in many other diseases, such as heart, lung and liver fibrosis, osteogenesis, angiogenesis and cancer, the new findings provide a rationale for novel concepts to investigate and potentially treat several pathologies.
Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Entities:  

Keywords:  Gremlin; VEGFR2; cancer; fibrosis; renal inflammation

Mesh：

Substances：

Year:  2015        PMID： 25875212     DOI： 10.1002/path.4544

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  9 in total

1.  Overexpression of Gremlin promotes non-small cell lung cancer progression.

Authors:  Yunhong Yin; Yie Yang; Liyun Yang; Yan Yang; Chunyu Li; Xiao Liu; Yiqing Qu
Journal:  Tumour Biol       Date:  2015-09-21

2.  Exercise Attenuates Acute β-Adrenergic Overactivation-Induced Cardiac Fibrosis by Modulating Cytokines.

Authors:  Akehu Alemasi; Ning Cao; Xiangbo An; Jimin Wu; Huijun Gu; Haiyi Yu; Yao Song; Huan Wang; Youyi Zhang; Han Xiao; Wei Gao
Journal:  J Cardiovasc Transl Res       Date:  2019-06-03       Impact factor: 4.132

3.  Regulation of Vegf signaling by natural and synthetic ligands.

Authors:  Andrea Rossi; Sebastien Gauvrit; Michele Marass; Luyuan Pan; Cecilia B Moens; Didier Y R Stainier
Journal:  Blood       Date:  2016-08-24       Impact factor: 22.113

4.  Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development.

Authors:  Oystein Eikrem; Christian Beisland; Karin Hjelle; Arnar Flatberg; Andreas Scherer; Lea Landolt; Trude Skogstrand; Sabine Leh; Vidar Beisvag; Hans-Peter Marti
Journal:  PLoS One       Date:  2016-02-22       Impact factor: 3.240

5.  REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature.

Authors:  Shavali Shaik; Bridget Kennis; Shinji Maegawa; Keri Schadler; Yang Yanwen; Keri Callegari; Rishi R Lulla; Stewart Goldman; Javad Nazarian; Veena Rajaram; Jason Fangusaro; Vidya Gopalakrishnan
Journal:  Oncotarget       Date:  2017-12-28

6.  Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.

Authors:  Song Ho Chang; Daisuke Mori; Hiroshi Kobayashi; Yoshifumi Mori; Hideki Nakamoto; Keita Okada; Yuki Taniguchi; Shurei Sugita; Fumiko Yano; Ung-Il Chung; Joo-Ri Kim-Kaneyama; Motoko Yanagita; Aris Economides; Ernesto Canalis; Di Chen; Sakae Tanaka; Taku Saito
Journal:  Nat Commun       Date:  2019-03-29       Impact factor: 14.919

7.  Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes.

Authors:  Maria-Luisa Pérez-Lozano; Laure Sudre; Sandy van Eegher; Danièle Citadelle; Audrey Pigenet; Marie-Helène Lafage-Proust; Philippe Pastoureau; Frédéric De Ceuninck; Francis Berenbaum; Xavier Houard
Journal:  Int J Mol Sci       Date:  2022-02-14       Impact factor: 5.923

Review 8.  Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression.

Authors:  Noha Mousaad Elemam; Abdullah Imadeddin Malek; Esraa Elaraby Mahmoud; Waseem El-Huneidi; Iman M Talaat
Journal:  Biomedicines       Date:  2022-01-28

9.  Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis.

Authors:  Laura Marquez-Exposito; Carolina Lavoz; Raul R Rodrigues-Diez; Sandra Rayego-Mateos; Macarena Orejudo; Elena Cantero-Navarro; Alberto Ortiz; Jesús Egido; Rafael Selgas; Sergio Mezzano; Marta Ruiz-Ortega
Journal:  Front Pharmacol       Date:  2018-10-17       Impact factor: 5.810
  9 in total

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