Hayrullah Derici1, Ismail Yaman2, Cemal Kara3, Erdinç Kamer4, Gülden Diniz5, Ragıp Ortac5. 1. Department of General Surgery, Balikesir Medical University, Balikesir, Turkey; email: hayrullahderici@yahoo.com. 2. Department of General Surgery, Balikesir Medical University, Balikesir, Turkey. 3. Department of General Surgery, Karsiyaka State Hospital, Izmir, Turkey. 4. Department of General Surgery, Atatürk Training and Research Hospital, Izmir, Turkey. 5. Department of Pathology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.
Abstract
UNLABELLED: This study investigated the effect of simvastatin on the heal- ing process of abdominal wall wounds in rats. METHODS: The study was performed with adult female Wistar-Albino rats. Control group (n = 20) rats were fed standard laboratory diet until 12 hours before sur- gery. Study group (n = 20) rats received oral simvastatin therapy with an orogastric tube (10 mg/kg once a day) for 7 days until 12 hours before surgery. Each rat was anesthetized, and a 4 cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 7 and 14. Breaking strength analysis was measured, and the abdominal incision wounds were examined histolog- ically. RESULTS: Hydroxyproline levels and tensile strength of abdominal fascia were significantly higher in the study group on PODs 7 and 14 compared to the control group. The granulation tissue fibroblast matu- ration scores on POD 7, and both collagen deposition scores and neo- vascularization scores on PODs 7 and 14, were found to be statistically significantly higher in the simvastatin treatment group compared to the control group, based on the results of the histologic tissue examina- tions. CONCLUSION: Simvastatin can be used as a supporting therapy in wound healing. .
UNLABELLED: This study investigated the effect of simvastatin on the heal- ing process of abdominal wall wounds in rats. METHODS: The study was performed with adult female Wistar-Albino rats. Control group (n = 20) rats were fed standard laboratory diet until 12 hours before sur- gery. Study group (n = 20) rats received oral simvastatin therapy with an orogastric tube (10 mg/kg once a day) for 7 days until 12 hours before surgery. Each rat was anesthetized, and a 4 cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 7 and 14. Breaking strength analysis was measured, and the abdominal incision wounds were examined histolog- ically. RESULTS:Hydroxyproline levels and tensile strength of abdominal fascia were significantly higher in the study group on PODs 7 and 14 compared to the control group. The granulation tissue fibroblast matu- ration scores on POD 7, and both collagen deposition scores and neo- vascularization scores on PODs 7 and 14, were found to be statistically significantly higher in the simvastatin treatment group compared to the control group, based on the results of the histologic tissue examina- tions. CONCLUSION:Simvastatin can be used as a supporting therapy in wound healing. .
Authors: Shankar Thangamani; Haroon Mohammad; Mostafa F N Abushahba; Maha I Hamed; Tiago J P Sobreira; Victoria E Hedrick; Lake N Paul; Mohamed N Seleem Journal: Sci Rep Date: 2015-11-10 Impact factor: 4.379