| Literature DB >> 2587441 |
B Serafin1, G Borkowska, J Główczyk, I Kowalska, S Rump.
Abstract
A series of benzimidazole derivatives was synthesized and tested for their hypotensive activity. The most interesting compounds were: BS1/81 (2-guanidino-benzimidazole) and BS1/84 (2-guanidino-5-aminobenzimidazole dihydrochloride), which effects were comparable to those of aminophylline. It was found that substitution of guanidine nitrogen atom with phenyl group caused a distinct decrease of activity while cyclization of guanidine rest to pyrimidine ring caused only a small decrease of activity.Entities:
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Year: 1989 PMID： 2587441
Source DB: PubMed Journal: Pol J Pharmacol Pharm ISSN： 0301-0244