Literature DB >> 2587436

The effect of microinjections of clonidine into the locus coeruleus on cortical EEG in rats.

W Danysz1, W Dyr, A Płaznik, W Kostowski.   

Abstract

Microinjections of clonidine into the locus coeruleus (LC) area synchronized rat cortical EEG. This effect of clonidine was attenuated by local pretreatment of rats with idazoxan, an alpha-2 adrenoceptor antagonist. The data indicate functional role of alpha-2 adrenoceptors within LC area in regulation of ceruleocortical activity, and point at the LC as one of brain targets for the sedative action of clonidine.

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Year:  1989        PMID： 2587436

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


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