Literature DB >> 25873169

Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.

Robert D Leone1, Maureen R Horton2, Jonathan D Powell3.   

Abstract

Recent clinical trials in cancer therapy have demonstrated unprecedented responses through blockade of CTLA-4 and PD-1 immune checkpoint pathways. In a provocative recent paper in Science Translational Medicine, Hatfield and colleagues demonstrate the ability of supplemental oxygen to act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25873169      PMCID： PMC4696011          DOI： 10.1016/j.ccell.2015.03.014

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  HIF transcription factors, inflammation, and immunity.

Authors:  Asis Palazon; Ananda W Goldrath; Victor Nizet; Randall S Johnson
Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

Review 2.  Hypoxia and hypoxia inducible factors in tumor metabolism.

Authors:  Wen Zeng; Peiyi Liu; Weimin Pan; Shree Ram Singh; Yiyong Wei
Journal:  Cancer Lett       Date:  2014-02-04       Impact factor: 8.679

Review 3.  Hyperoxic acute lung injury.

Authors:  Richard H Kallet; Michael A Matthay
Journal:  Respir Care       Date:  2013-01       Impact factor: 2.258

4.  Immunological mechanisms of the antitumor effects of supplemental oxygenation.

Authors:  Stephen M Hatfield; Jorgen Kjaergaard; Dmitriy Lukashev; Taylor H Schreiber; Bryan Belikoff; Robert Abbott; Shalini Sethumadhavan; Phaethon Philbrook; Kami Ko; Ryan Cannici; Molly Thayer; Scott Rodig; Jeffrey L Kutok; Edwin K Jackson; Barry Karger; Eckhard R Podack; Akio Ohta; Michail V Sitkovsky
Journal:  Sci Transl Med       Date:  2015-03-04       Impact factor: 17.956

5.  Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release.

Authors:  U K Decking; G Schlieper; K Kroll; J Schrader
Journal:  Circ Res       Date:  1997-08       Impact factor: 17.367

Review 6.  Targeting cancer-derived adenosine: new therapeutic approaches.

Authors:  Arabella Young; Deepak Mittal; John Stagg; Mark J Smyth
Journal:  Cancer Discov       Date:  2014-07-17       Impact factor: 39.397

7.  T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response.

Authors:  Michail V Sitkovsky
Journal:  Trends Immunol       Date:  2009-02-07       Impact factor: 16.687

8.  Postoperative hyperoxia (60%) worsens hepatic injury in mice.

Authors:  Quirin Zangl; André Martignoni; Sharon H Jackson; Akio Ohta; Brenda Klaunberg; Ines Kaufmann; Dimitry Lukashev; Jerrold M Ward; Michail Sitkovsky; Manfred Thiel; Alexander Choukèr
Journal:  Anesthesiology       Date:  2014-12       Impact factor: 7.892

9.  PD-1 blockade induces responses by inhibiting adaptive immune resistance.

Authors:  Paul C Tumeh; Christina L Harview; Jennifer H Yearley; I Peter Shintaku; Emma J M Taylor; Lidia Robert; Bartosz Chmielowski; Marko Spasic; Gina Henry; Voicu Ciobanu; Alisha N West; Manuel Carmona; Christine Kivork; Elizabeth Seja; Grace Cherry; Antonio J Gutierrez; Tristan R Grogan; Christine Mateus; Gorana Tomasic; John A Glaspy; Ryan O Emerson; Harlan Robins; Robert H Pierce; David A Elashoff; Caroline Robert; Antoni Ribas
Journal:  Nature       Date:  2014-11-27       Impact factor: 49.962
  9 in total
  17 in total

Review 1.  Resistance to immunotherapy: clouds in a bright sky.

Authors:  Gérard Milano
Journal:  Invest New Drugs       Date:  2017-04-12       Impact factor: 3.850

Review 2.  Acute vs. chronic vs. intermittent hypoxia in breast Cancer: a review on its application in in vitro research.

Authors:  Qiuyu Liu; Victoria A C Palmgren; Erik Hj Danen; Sylvia E Le Dévédec
Journal:  Mol Biol Rep       Date:  2022-09-03       Impact factor: 2.742

Review 3.  Myeloid cells in the tumor microenvironment: Role of adenosine.

Authors:  Silvana Morello; Aldo Pinto; Corrado Blandizzi; Luca Antonioli
Journal:  Oncoimmunology       Date:  2015-12-03       Impact factor: 8.110

4.  Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.

Authors:  Xiaomeng Guo; Jiaxin Qu; Chunqi Zhu; Wei Li; Lihua Luo; Jie Yang; Xiaoyi Yin; Qingpo Li; Yongzhong Du; Dawei Chen; Yunqing Qiu; Yan Lou; Jian You
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419

Review 5.  Targeting adenosine for cancer immunotherapy.

Authors:  Robert D Leone; Leisha A Emens
Journal:  J Immunother Cancer       Date:  2018-06-18       Impact factor: 13.751

6.  Adenosinergic Signaling Alters Natural Killer Cell Functional Responses.

Authors:  Andrea M Chambers; Jiao Wang; Kyle B Lupo; Hao Yu; Nadia M Atallah Lanman; Sandro Matosevic
Journal:  Front Immunol       Date:  2018-10-30       Impact factor: 7.561

Review 7.  Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment.

Authors:  Kaitlin Graham; Evan Unger
Journal:  Int J Nanomedicine       Date:  2018-10-04

8.  Transcutaneous Carbon Dioxide Decreases Immunosuppressive Factors in Squamous Cell Carcinoma In Vivo.

Authors:  Nanae Yatagai; Takumi Hasegawa; Rika Amano; Izumi Saito; Satomi Arimoto; Daisuke Takeda; Yasumasa Kakei; Masaya Akashi
Journal:  Biomed Res Int       Date:  2021-07-02       Impact factor: 3.411

9.  Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.

Authors:  Stephen M Hatfield; Michail Sitkovsky
Journal:  Oncoimmunology       Date:  2015-06-01       Impact factor: 8.110

10.  Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS.

Authors:  Carole Y Perrot; Junko Sawada; Masanobu Komatsu
Journal:  FASEB J       Date:  2018-05-18       Impact factor: 5.191
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