Literature DB >> 25873168

When one mutation is all it takes.

Mel Greaves1.   

Abstract

In a recent issue of Nature Genetics, Andersson and colleagues report that MLL fusion alone may be sufficient to spawn an aggressive leukemia in infants. Some other pediatric cancers may share a similar, single, "big-hit" origin, possibly reflecting a critical developmental window of stem cell vulnerability.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25873168     DOI： 10.1016/j.ccell.2015.03.016

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  15 in total

1.  Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia.

Authors:  Andrii I Rozhok; Jennifer L Salstrom; James DeGregori
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-11       Impact factor: 11.205

Review 2.  Mutations, Cancer and the Telomere Length Paradox.

Authors:  Abraham Aviv; James J Anderson; Jerry W Shay
Journal:  Trends Cancer       Date:  2017-03-27

Review 3.  Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.

Authors:  Alejandra Sanjuan-Pla; Clara Bueno; Cristina Prieto; Pamela Acha; Ronald W Stam; Rolf Marschalek; Pablo Menéndez
Journal:  Blood       Date:  2015-10-13       Impact factor: 22.113

4.  Non-genetic determinants of malignant clonal fitness at single-cell resolution.

Authors:  Katie A Fennell; Dane Vassiliadis; Enid Y N Lam; Luciano G Martelotto; Jesse J Balic; Sebastian Hollizeck; Tom S Weber; Timothy Semple; Qing Wang; Denise C Miles; Laura MacPherson; Yih-Chih Chan; Andrew A Guirguis; Lev M Kats; Emily S Wong; Sarah-Jane Dawson; Shalin H Naik; Mark A Dawson
Journal:  Nature       Date:  2021-12-08       Impact factor: 69.504

5.  Exploitable metabolic dependencies in MLL-ENL-induced leukemia.

Authors:  Maria-Paz Garcia-Cuellar; Jennifer Lawlor; Martin Böttcher; Dimitrios Mougiakakos; Markus Metzler; Robert K Slany
Journal:  Blood Adv       Date:  2020-08-11

6.  Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.

Authors:  Krinio Giannikou; Izabela A Malinowska; Trevor J Pugh; Rachel Yan; Yuen-Yi Tseng; Coyin Oh; Jaegil Kim; Magdalena E Tyburczy; Yvonne Chekaluk; Yang Liu; Nicola Alesi; Geraldine A Finlay; Chin-Lee Wu; Sabina Signoretti; Matthew Meyerson; Gad Getz; Jesse S Boehm; Elizabeth P Henske; David J Kwiatkowski
Journal:  PLoS Genet       Date:  2016-08-05       Impact factor: 5.917

7.  The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism.

Authors:  Alessa Kühn; Denise Löscher; Rolf Marschalek
Journal:  Oncotarget       Date:  2016-06-07

8.  Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor.

Authors:  Swethajit Biswas; Madeleine Wood; Abhijit Joshi; Nick Bown; Lisa Strain; Tommy Martinsson; James Campbell; Alan Ashworth; Amanda Swain
Journal:  Front Oncol       Date:  2015-10-23       Impact factor: 6.244

9.  Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study.

Authors:  Sameera Ezzat; Wafaa M Rashed; Sherin Salem; M Tevfik Dorak; Mai El-Daly; Mohamed Abdel-Hamid; Iman Sidhom; Alaa El-Hadad; Christopher Loffredo
Journal:  BMC Cancer       Date:  2016-08-20       Impact factor: 4.430

Review 10.  Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.

Authors:  Rolf Marschalek
Journal:  Ann Lab Med       Date:  2016-03       Impact factor: 3.464
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