Literature DB >> 25873167

Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia.

Michael W M Kühn1, Scott A Armstrong2.   

Abstract

The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity. In this issue of Cancer Cell, Borkin and colleagues describe the development of highly potent small-molecule inhibitors of this interaction that reverse the leukemic phenotype and prolong survival in murine models of MLL-rearranged leukemia.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25873167     DOI： 10.1016/j.ccell.2015.03.012

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  Potential Treatment of Acute Leukemia with Inhibitors of Menin/MLL Interaction.

Authors:  Ahmed F Abdel-Magid
Journal:  ACS Med Chem Lett       Date:  2018-08-06       Impact factor: 4.345

2.  Relapsed acute lymphoblastic leukaemia after allogeneic stem cell transplantation: a therapeutic dilemma challenging the armamentarium of immunotherapies currently available (case reports).

Authors:  Fiona Poyer; Anna Füreder; Wolfgang Holter; Christina Peters; Heidrun Boztug; Michael Dworzak; Gernot Engstler; Waltraud Friesenbichler; Stefan Köhrer; Roswitha Lüftinger; Leila Ronceray; Volker Witt; Herbert Pichler; Andishe Attarbaschi
Journal:  Ther Adv Hematol       Date:  2022-05-23

3.  Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway.

Authors:  Yuan Wu; Miriam Doepner; Taylor Hojnacki; Zijie Feng; Bryson W Katona; Xin He; Jian Ma; Yan Cao; Luca Busino; Fuxiang Zhou; Xianxin Hua
Journal:  Am J Cancer Res       Date:  2019-08-01       Impact factor: 6.166

Review 4.  Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.

Authors:  Agnieszka Bochyńska; Juliane Lüscher-Firzlaff; Bernhard Lüscher
Journal:  Cells       Date:  2018-03-02       Impact factor: 6.600

5.  Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair.

Authors:  Jing Ye; Jie Zha; Yuanfei Shi; Yin Li; Delin Yuan; Qinwei Chen; Fusheng Lin; Zhihong Fang; Yong Yu; Yun Dai; Bing Xu
Journal:  Clin Epigenetics       Date:  2019-10-07       Impact factor: 6.551

Review 6.  Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation.

Authors:  Florian Perner; Scott A Armstrong
Journal:  Cells       Date:  2020-12-21       Impact factor: 6.600

7.  Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF‑ß Inhibition as Revealed by A Refined Primary Culture Screening.

Authors:  Saghar Pahlavanneshan; Mehrdad Behmanesh; Yaser Tahamtani; Ensiyeh Hajizadeh-Saffar; Mohsen Basiri; Hossein Baharvand
Journal:  Cell J       Date:  2021-11-23       Impact factor: 2.479
  7 in total

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