| Literature DB >> 25873166 |
Margaret C Frame1, Alan Serrels2.
Abstract
Perhaps the most pressing need in cancer therapeutics is to understand drug resistance. In this issue of Cancer Cell, Hirata and colleagues show that melanoma-associated fibroblasts can drive resistance to the BRAF inhibitor PLX4720 by stimulating matrix production/remodeling, and, consequently, survival signaling in melanoma cells via β1-integrin, Src, and FAK.Entities:
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Year: 2015 PMID： 25873166 DOI： 10.1016/j.ccell.2015.03.013
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743