| Literature DB >> 25873165 |
Michaela Seeling1, Falk Nimmerjahn2.
Abstract
The inhibitory Fcγ receptor modulates therapeutic antibody activity by setting a threshold for effector cell activation and removing antibodies from the tumor cell surface. In this issue of Cancer Cell, Roghanian and colleagues demonstrate that antibodies blocking inhibitory Fcγ receptor function can enhance therapeutic antibody activity to allow optimal tumor cell depletion.Entities:
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Year: 2015 PMID： 25873165 DOI： 10.1016/j.ccell.2015.03.011
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743