| Literature DB >> 25873085 |
Giarita Ferraro1, Lara Massai, Luigi Messori, Antonello Merlino.
Abstract
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.Entities:
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Year: 2015 PMID: 25873085 DOI: 10.1039/c5cc01751c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN: 1359-7345 Impact factor: 6.222