| Literature DB >> 25873049 |
Li Peng1, Xiao Qing Yuan2, Guan Cheng Li1.
Abstract
Circular RNAs (circRNAs) are a novel class of non-coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exert specific biological effects. Also, ciRS-7 acts as a natural competing endogenous RNA, a.k.a. 'super sponge' of microRNA-7 (miR-7) that sequesters and competitively inhibits the activity of miR-7. This competition between ciRS-7 and miR-7 may have profound effects on oncogenesis. This review will summarize the origin and functions of ciRS-7 and discuss the relationship among ciRS-7, its target molecules and cancer.Entities:
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Year: 2015 PMID： 25873049 DOI： 10.3892/or.2015.3904
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906