BACKGROUND/AIMS: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. METHODS: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System. RESULTS: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. CONCLUSIONS: Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.
BACKGROUND/AIMS: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. METHODS: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System. RESULTS: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. CONCLUSIONS: Our data evidenced that rs10830963MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.
Authors: Leticia Goni; Dianjianyi Sun; Yoriko Heianza; Tiange Wang; Tao Huang; J Alfredo Martínez; Xiaoyun Shang; George A Bray; Steven R Smith; Frank M Sacks; Lu Qi Journal: Eur J Nutr Date: 2018-03-07 Impact factor: 5.614
Authors: Nora E Grotenfelt; Niko S Wasenius; Kristiina Rönö; Hannele Laivuori; Beata Stach-Lempinen; Marju Orho-Melander; Christina-Alexandra Schulz; Hannu Kautiainen; Saila B Koivusalo; Johan G Eriksson Journal: Diabetologia Date: 2016-05-21 Impact factor: 10.122
Authors: Katherine M Livingstone; Carlos Celis-Morales; George D Papandonatos; Bahar Erar; Jose C Florez; Kathleen A Jablonski; Cristina Razquin; Amelia Marti; Yoriko Heianza; Tao Huang; Frank M Sacks; Mathilde Svendstrup; Xuemei Sui; Timothy S Church; Tiina Jääskeläinen; Jaana Lindström; Jaakko Tuomilehto; Matti Uusitupa; Tuomo Rankinen; Wim H M Saris; Torben Hansen; Oluf Pedersen; Arne Astrup; Thorkild I A Sørensen; Lu Qi; George A Bray; Miguel A Martinez-Gonzalez; J Alfredo Martinez; Paul W Franks; Jeanne M McCaffery; Jose Lara; John C Mathers Journal: BMJ Date: 2016-09-20