Literature DB >> 25870232

Tregs strip dendritic cells of CD70 to regulate Th1 differentiation.

Lukasz Wojciech1, Leszek Ignatowicz1.   

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Year:  2015        PMID： 25870232      PMCID： PMC4491990          DOI： 10.15252/embj.201591547

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


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3.  Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

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4.  The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.

Authors:  Jonathan M Coquet; Sabine Middendorp; Gerda van der Horst; Jop Kind; Elise A M Veraar; Yanling Xiao; Heinz Jacobs; Jannie Borst
Journal:  Immunity       Date:  2012-11-15       Impact factor: 31.745

5.  CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.

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6.  Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.

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7.  Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

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8.  A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.

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9.  The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.

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10.  Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.

Authors:  Ye Zheng; Ashutosh Chaudhry; Arnold Kas; Paul deRoos; Jeong M Kim; Tin-Tin Chu; Lynn Corcoran; Piper Treuting; Ulf Klein; Alexander Y Rudensky
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Review 1.  Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.

Authors:  Timothy Nj Bullock
Journal:  Curr Opin Immunol       Date:  2017-03-17       Impact factor: 7.486
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