Collet Dandara1, Barbara Robertson2, Kevin Dzobo3, Loven Moodley4, M Iqbal Parker5. 1. Division of Human Genetics, Faculty of Health Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa collet.dandara@uct.ac.za. 2. Department of Radiation Oncology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa. 3. International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa. 4. Chris Barnard Department of Cardiothoracic Surgery, University of Cape Town, South Africa. 5. International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Abstract
OBJECTIVES: In addition to the high incidence of squamous carcinoma of the oesophagus among South African men, the neoplasm is also characterized by an exceptionally latent course and poor prognosis. The aim of this study was to review a cohort of patients with carcinoma of the oesophagus presenting to the Groote Schuur Hospital, Cape Town and evaluate patient and tumour characteristics for their role as prognostic markers for survival. METHODS: Information on patients was extracted from a database established and maintained over a 30-year period. Information for the analysis included patient demographics, clinical symptoms at presentation, tumour characteristics and treatment decisions. Statistical analyses were performed using GraphPad Prism 5 applying chi-square and Kaplan-Meier tests. RESULTS: Data were available on 1868 patients. The majority of patients were Black African men and the predominant histology was squamous cell carcinoma. There were significant differences (P < 0.05) in the survival of patients with respect to race (P < 0.001), performance status (P < 0.001), weight loss (P = 0.001) and prior tuberculosis diagnosis (P = 0.007). Tumour characteristics that were significantly associated with survival were histological type, tumour size and site. Gender, prior cancer, smoking status and tumour-related pain did not show significant association with survival in patients with oesophageal cancer. Only 19.8% of the patients were candidates for potentially curative treatment. CONCLUSIONS: This analysis shows that there are prominent patient and tumour characteristics that are significantly associated with survival with respect to oesophageal carcinoma. The inclusion of these factors in the initial assessment of patients may assist with appropriate treatment decisions.
OBJECTIVES: In addition to the high incidence of squamous carcinoma of the oesophagus among South African men, the neoplasm is also characterized by an exceptionally latent course and poor prognosis. The aim of this study was to review a cohort of patients with carcinoma of the oesophagus presenting to the Groote Schuur Hospital, Cape Town and evaluate patient and tumour characteristics for their role as prognostic markers for survival. METHODS: Information on patients was extracted from a database established and maintained over a 30-year period. Information for the analysis included patient demographics, clinical symptoms at presentation, tumour characteristics and treatment decisions. Statistical analyses were performed using GraphPad Prism 5 applying chi-square and Kaplan-Meier tests. RESULTS: Data were available on 1868 patients. The majority of patients were Black African men and the predominant histology was squamous cell carcinoma. There were significant differences (P < 0.05) in the survival of patients with respect to race (P < 0.001), performance status (P < 0.001), weight loss (P = 0.001) and prior tuberculosis diagnosis (P = 0.007). Tumour characteristics that were significantly associated with survival were histological type, tumour size and site. Gender, prior cancer, smoking status and tumour-related pain did not show significant association with survival in patients with oesophageal cancer. Only 19.8% of the patients were candidates for potentially curative treatment. CONCLUSIONS: This analysis shows that there are prominent patient and tumour characteristics that are significantly associated with survival with respect to oesophageal carcinoma. The inclusion of these factors in the initial assessment of patients may assist with appropriate treatment decisions.
Authors: Daniel R S Middleton; Liacine Bouaoun; Rachel Hanisch; Freddie Bray; Charles Dzamalala; Steady Chasimpha; Diana Menya; Charles Gombé Mbalawa; Guy N'Da; Mathewos A Woldegeorgis; Ramou Njie; Moussa Koulibaly; Nathan Buziba; Josefo Ferro; Hassan Nouhou; Femi Ogunbiyi; Henry R Wabinga; Eric Chokunonga; Margaret Z Borok; Anne R Korir; Amos O Mwasamwaja; Blandina T Mmbaga; Joachim Schüz; Valerie A McCormack Journal: Cancer Epidemiol Date: 2018-02-06 Impact factor: 2.984
Authors: Geoffrey C Buckle; Alita Mrema; Michael Mwachiro; Yona Ringo; Msiba Selekwa; Gift Mulima; Fatma F Some; Blandina T Mmbaga; Gita N Mody; Li Zhang; Alan Paciorek; Larry Akoko; Paul Ayuo; Stephen Burgert; Elizabeth Bukusi; Anthony Charles; Winnie Chepkemoi; Gladys Chesumbai; Bongani Kaimila; Aida Kenseko; Kitembo Salum Kibwana; David Koech; Caren Macharia; Ezekiel N Moirana; Beatrice Paul Mushi; Alex Mremi; Julius Mwaiselage; Ally Mwanga; Jerry Ndumbalo; Gissela Nvakunga; Mamsau Ngoma; Margaret Oduor; Mark Oloo; Jesse Opakas; Robert Parker; Saruni Seno; Ande Salima; Furaha Servent; Andrew Wandera; Kate D Westmoreland; Russell E White; Brittney Williams; Elia J Mmbaga; Katherine Van Loon Journal: BMC Cancer Date: 2022-01-19 Impact factor: 4.430