Literature DB >> 25869956

Psoralen derivatives as inhibitors of NF-κB interaction: the critical role of the furan ring.

Giovanni Marzaro1, Ilaria Lampronti, Monica Borgatti, Paolo Manzini, Roberto Gambari, Adriana Chilin.   

Abstract

Simplified analogues of previously reported NF-κB interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-κB.

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Year:  2015        PMID： 25869956     DOI： 10.1007/s11030-015-9586-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  44 in total

1.  Open3DQSAR: a new open-source software aimed at high-throughput chemometric analysis of molecular interaction fields.

Authors:  Paolo Tosco; Thomas Balle
Journal:  J Mol Model       Date:  2010-04-11       Impact factor: 1.810

2.  NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiation.

Authors:  Guangyun Tan; Jixiao Niu; Yuling Shi; Hongsheng Ouyang; Zhao-Hui Wu
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157

3.  Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.

Authors:  Valentino Bezzerri; Monica Borgatti; Alessia Finotti; Anna Tamanini; Roberto Gambari; Giulio Cabrini
Journal:  J Immunol       Date:  2011-10-26       Impact factor: 5.422

4.  Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.

Authors:  Monica Borgatti; Adriana Chilin; Laura Piccagli; Ilaria Lampronti; Nicoletta Bianchi; Irene Mancini; Giovanni Marzaro; Francesco dall'Acqua; Adriano Guiotto; Roberto Gambari
Journal:  Eur J Med Chem       Date:  2011-07-23       Impact factor: 6.514

5.  Inflammatory cytokines in cystic fibrosis lungs.

Authors:  T L Bonfield; J R Panuska; M W Konstan; K A Hilliard; J B Hilliard; H Ghnaim; M Berger
Journal:  Am J Respir Crit Care Med       Date:  1995-12       Impact factor: 21.405

6.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.

Authors:  Garrett M Morris; Ruth Huey; William Lindstrom; Michel F Sanner; Richard K Belew; David S Goodsell; Arthur J Olson
Journal:  J Comput Chem       Date:  2009-12       Impact factor: 3.376

7.  Virtual screening against p50 NF-kappaB transcription factor for the identification of inhibitors of the NF-kappaB-DNA interaction and expression of NF-kappaB upregulated genes.

Authors:  Laura Piccagli; Enrica Fabbri; Monica Borgatti; Nicoletta Bianchi; Valentino Bezzerri; Irene Mancini; Elena Nicolis; Cristina M Dechecchi; Ilaria Lampronti; Giulio Cabrini; Roberto Gambari
Journal:  ChemMedChem       Date:  2009-12       Impact factor: 3.466

8.  Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.

Authors:  Roberto Gambari; Monica Borgatti; Ilaria Lampronti; Enrica Fabbri; Eleonora Brognara; Nicoletta Bianchi; Laura Piccagli; Marcus Chun-Wah Yuen; Chi-Wai Kan; Desmond Kwok-Po Hau; Wang-Fun Fong; Wai-Yeung Wong; Raymond Siu-Ming Wong; Chung-Hin Chui
Journal:  Int Immunopharmacol       Date:  2012-05-04       Impact factor: 4.932

Review 9.  The diverse and complex roles of NF-κB subunits in cancer.

Authors:  Neil D Perkins
Journal:  Nat Rev Cancer       Date:  2012-01-19       Impact factor: 60.716

10.  Avogadro: an advanced semantic chemical editor, visualization, and analysis platform.

Authors:  Marcus D Hanwell; Donald E Curtis; David C Lonie; Tim Vandermeersch; Eva Zurek; Geoffrey R Hutchison
Journal:  J Cheminform       Date:  2012-08-13       Impact factor: 5.514
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  2 in total

1.  4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.

Authors:  Sujin Lee; Onur Cil; Peter M Haggie; Alan S Verkman
Journal:  J Med Chem       Date:  2019-09-03       Impact factor: 7.446

2.  Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.

Authors:  Onofrio Laselva; Giovanni Marzaro; Christian Vaccarin; Ilaria Lampronti; Anna Tamanini; Giuseppe Lippi; Roberto Gambari; Giulio Cabrini; Christine E Bear; Adriana Chilin; Maria C Dechecchi
Journal:  Front Pharmacol       Date:  2018-07-04       Impact factor: 5.810
  2 in total

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