Bahadır Ceylan1,2, Turan Aslan3, Ahmet Çınar4, Ayşe Ruhkar Kurt3, Yasemin Akkoyunlu3. 1. Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey. bceylan2004@yahoo.com. 2. , Yıldırım Beyazıt Caddesi, Zafer Mahallesi, Bosnapark Evleri, No: 8, Daire 13, Kat 3, Yenibosna, Bahçelievler, Istanbul, Turkey. bceylan2004@yahoo.com. 3. Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey. 4. Medical Faculty, Department of Internal Diseases, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey.
Abstract
BACKGROUND: We examined the changes of mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with appendicitis and whether MPV and PDW could be used to predict the development of complication due to appendicitis. METHODS: The healthy control group, the cases of appendicitis with perforation, and the cases of appendicitis without perforation were compared with regard to MPV and PDW. We determined whether MPV and PDW were independent variables predictive of the development of complication in subjects with appendicitis. RESULTS: This retrospective case-control study included a total of 362 patients (249 of which were male (68.8 %) and 113 were female (31.2 %); median age, 30 [range, 18-84 years]). One hundred and ninety-two subjects (53 %) presented with appendicitis and 170 (47 %) comprised the healthy control group. Sixty-six (18.2 %) of the subjects with appendicitis developed complication. MPVs were lower in subjects of appendicitis without complication compared to the subjects of appendicitis with complication and the control group (MPV, 9.78 ± 0.99 vs. 10.20 ± 1.21 and 10.14 ± 1.03, respectively [p = 0.005]). The PDW levels were not different between the three groups. Independent variables predictive of the presence of complication included increased MPV and time from onset of symptoms to hospital presentation (odds ratio[confidence interval], p-value: 1.507[1.064-2.133], 0.021 and 18.887[5.139-69.410], 0.0001, respectively). CONCLUSIONS: Our findings suggested these, MPV values in cases of appendicitis without complication were lower than the cases with complication and healthy control and MPV is a predictor of the development of complication in subjects with appendicitis.
BACKGROUND: We examined the changes of mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with appendicitis and whether MPV and PDW could be used to predict the development of complication due to appendicitis. METHODS: The healthy control group, the cases of appendicitis with perforation, and the cases of appendicitis without perforation were compared with regard to MPV and PDW. We determined whether MPV and PDW were independent variables predictive of the development of complication in subjects with appendicitis. RESULTS: This retrospective case-control study included a total of 362 patients (249 of which were male (68.8 %) and 113 were female (31.2 %); median age, 30 [range, 18-84 years]). One hundred and ninety-two subjects (53 %) presented with appendicitis and 170 (47 %) comprised the healthy control group. Sixty-six (18.2 %) of the subjects with appendicitis developed complication. MPVs were lower in subjects of appendicitis without complication compared to the subjects of appendicitis with complication and the control group (MPV, 9.78 ± 0.99 vs. 10.20 ± 1.21 and 10.14 ± 1.03, respectively [p = 0.005]). The PDW levels were not different between the three groups. Independent variables predictive of the presence of complication included increased MPV and time from onset of symptoms to hospital presentation (odds ratio[confidence interval], p-value: 1.507[1.064-2.133], 0.021 and 18.887[5.139-69.410], 0.0001, respectively). CONCLUSIONS: Our findings suggested these, MPV values in cases of appendicitis without complication were lower than the cases with complication and healthy control and MPV is a predictor of the development of complication in subjects with appendicitis.
Entities:
Keywords:
Appendicitis; Blood platelets; Complications; Intestinal perforation; Mean platelet volume
Authors: Bunyamin Uyanik; Cemil Kavalci; Engin Deniz Arslan; Fevzi Yilmaz; Ozgur Aslan; Serdal Dede; Fatih Bakir Journal: Emerg Med Int Date: 2012-08-27 Impact factor: 1.112
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