Metin Basaranoglu1, Billur Canbakan2, Kemal Yildiz2, Bahadir Ceylan2, Birol Baysal2, Omer Uysal2, Hakan Senturk2. 1. Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey. metin_basaranoglu@yahoo.com. 2. Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
Abstract
BACKGROUND: Fatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives. METHODS: In this study, we evaluated 105 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD), 121 patients with hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia as a control group. RESULTS: There was no difference for sex, mean age, and marital status among the groups, except that patients with IBD were younger than others (p < 0.001). The frequency of cancer in family was as follows: 18 % in IBD, 9 % in dyspepsia, 28 % in hepatitis C with hepatic steatosis, 21.5 % in hepatitis C without steatosis, and 27 % in NAFLD (p = 0.006). Then, we divided the study group into two groups-group 1: IBD + dyspepsia + hepatitis C without hepatic steatosis, and group 2: hepatitis C with hepatic steatosis + NAFLD-and performed the same analysis. We found that the frequency of cancer in family was 16 % in group 1 (the patients without fatty liver) vs. 24.4 % in group 2 (those with fatty liver; p = 0.037). We also investigated the rate of operation in patients. The results were as follows: 33 % in group 1 vs. 43 % in group 2 (p = 0.043). CONCLUSIONS: Independently of the underlying chronic diseases, occurrence of fat in the liver increased the frequency of operation in patients with fatty liver and the rate of cancer in their first-degree relatives. Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operation in patients with fatty liver.
RCT Entities:
BACKGROUND:Fatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives. METHODS: In this study, we evaluated 105 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD), 121 patients with hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia as a control group. RESULTS: There was no difference for sex, mean age, and marital status among the groups, except that patients with IBD were younger than others (p < 0.001). The frequency of cancer in family was as follows: 18 % in IBD, 9 % in dyspepsia, 28 % in hepatitis C with hepatic steatosis, 21.5 % in hepatitis C without steatosis, and 27 % in NAFLD (p = 0.006). Then, we divided the study group into two groups-group 1: IBD + dyspepsia + hepatitis C without hepatic steatosis, and group 2: hepatitis C with hepatic steatosis + NAFLD-and performed the same analysis. We found that the frequency of cancer in family was 16 % in group 1 (the patients without fatty liver) vs. 24.4 % in group 2 (those with fatty liver; p = 0.037). We also investigated the rate of operation in patients. The results were as follows: 33 % in group 1 vs. 43 % in group 2 (p = 0.043). CONCLUSIONS: Independently of the underlying chronic diseases, occurrence of fat in the liver increased the frequency of operation in patients with fatty liver and the rate of cancer in their first-degree relatives. Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operation in patients with fatty liver.
Authors: Brent A Neuschwander-Tetri; David A Ford; Sahaja Acharya; George Gilkey; Metin Basaranoglu; Laura H Tetri; Elizabeth M Brunt Journal: Lipids Date: 2012-08-26 Impact factor: 1.880
Authors: Ravi Dhingra; Lisa Sullivan; Paul F Jacques; Thomas J Wang; Caroline S Fox; James B Meigs; Ralph B D'Agostino; J Michael Gaziano; Ramachandran S Vasan Journal: Circulation Date: 2007-07-23 Impact factor: 29.690
Authors: Laura H Tetri; Metin Basaranoglu; Elizabeth M Brunt; Lisa M Yerian; Brent A Neuschwander-Tetri Journal: Am J Physiol Gastrointest Liver Physiol Date: 2008-09-04 Impact factor: 4.052