Adnan Incebiyik1, Mehmet Vural2, Hakan Camuzcuoglu3, Abdullah Taskin4, Aysun Camuzcuoglu3, Nese Gul Hilali3, Nurten Aksoy4. 1. Faculty of Medicine, Department of Gynecology and Obstetrics, Harran University, Yenisehir Campus, 63300, Sanliurfa, Turkey. dr.aincebiyik@gmail.com. 2. Faculty of Medicine, Department of Gynecology and Obstetrics, Marmara University, Istanbul, Turkey. 3. Faculty of Medicine, Department of Gynecology and Obstetrics, Harran University, Yenisehir Campus, 63300, Sanliurfa, Turkey. 4. Faculty of Medicine, Department of Biochemistry, Harran University, Sanliurfa, Turkey.
Abstract
OBJECTIVE: The objective of this study is to evaluate the prognostic value of M30 and M65 levels as markers of apoptotic activity and maternal serum oxidative stress in patients with complete hydatidiform mole (CHM). METHODS: In total, 68 pregnant women were included in the study. The study group included 34 pregnant with CHM, while 34 healthy pregnant were employed as a control group. Venous blood samples were drawn to assess the maternal serum oxidative stress and M30-M65 levels. In addition, a second blood sample was drawn from patients with CHM on day 8 after dilatation evacuation. RESULTS: Maternal serum oxidative stress and M30-M65 levels were found to be significantly higher in patients with CHM as compared with the control group. It was found that serum β-subunit of human chorionic gonadotropin (β-hCG) level had a significant positive correlation with M30-M65 levels in patients with CHM. In addition, serum M65 level was found to be as effective as β-hCG in the identification of the patients with CHM. CONCLUSION: Our results indicated that oxidative stress and apoptosis may play significant roles in CHM development. In addition, it seems that serum M30-M65 levels can presumably be an ancillary laboratory test to β-hCG in the diagnosis and follow-up of the patients with CHM.
OBJECTIVE: The objective of this study is to evaluate the prognostic value of M30 and M65 levels as markers of apoptotic activity and maternal serum oxidative stress in patients with complete hydatidiform mole (CHM). METHODS: In total, 68 pregnant women were included in the study. The study group included 34 pregnant with CHM, while 34 healthy pregnant were employed as a control group. Venous blood samples were drawn to assess the maternal serum oxidative stress and M30-M65 levels. In addition, a second blood sample was drawn from patients with CHM on day 8 after dilatation evacuation. RESULTS: Maternal serum oxidative stress and M30-M65 levels were found to be significantly higher in patients with CHM as compared with the control group. It was found that serum β-subunit of human chorionic gonadotropin (β-hCG) level had a significant positive correlation with M30-M65 levels in patients with CHM. In addition, serum M65 level was found to be as effective as β-hCG in the identification of the patients with CHM. CONCLUSION: Our results indicated that oxidative stress and apoptosis may play significant roles in CHM development. In addition, it seems that serum M30-M65 levels can presumably be an ancillary laboratory test to β-hCG in the diagnosis and follow-up of the patients with CHM.
Authors: Hakan Buyukhatipoglu; Idris Kirhan; Mehmet Vural; Abdullah Taskin; Yusuf Sezen; Omer Faruk Dag; Mehmet Nuri Turan; Nurten Aksoy Journal: Am J Med Sci Date: 2010-12 Impact factor: 2.378
Authors: Victor C Y Mak; Lee Lee; Michelle K Y Siu; Oscar G W Wong; Xin Lu; Hextan Y S Ngan; Esther S Y Wong; Annie N Y Cheung Journal: Mod Pathol Date: 2010-11-19 Impact factor: 7.842
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