Beom-hee Choi1, Nam-Seok Joo2, Moon Jong Kim3, Kwang-Min Kim2, Kyung-Chae Park3, Young-Sang Kim3. 1. Department of Family Medicine, Chaum Medical Checkup Center Samseongdong Branch, CHA University, Seoul, Korea. 2. Department of Family Practice and Community Health, School of Medicine, Ajou University, Suwon, Korea. 3. Department of Family Medicine, CHA Bundang Medical Centre, CHA University, Seongnam, Korea.
Abstract
CONTEXT: Osteocalcin is associated with energy metabolism and atherosclerosis, besides bone metabolism. However, the association between osteocalcin or its undercarboxylated form (ucOC) and coronary artery calcification is controversial. OBJECTIVE: To evaluate the relationship between coronary artery calcium score (CACS) and the concentration of serum osteocalcin and ucOC. DESIGN: Cross-sectional. PATIENTS: A total of 162 subjects (114 men and 48 women) with no angina symptom. MEASUREMENTS: Serum analyses included glucose, insulin and lipid profiles as well as osteocalcin and ucOC. Bone mineral density (BMD) was measured by dual X-ray absorptiometry. CACS was measured using multidetector computed tomography and categorized into CACS = 0 and CACS > 0. RESULTS: The mean osteocalcin concentration in men was 15·6 ± 4·2 for CACS = 0 group and 14·1 ± 4·0 for CACS > 0 group, respectively (P = 0·050). In women, the osteocalcin concentration, ucOC concentration and ucOC to osteocalcin ratio (OCR) were not different between the CACS groups. However, the concentrations of osteocalcin and ucOC were significantly lower in women with hypertension or diabetes than those without, respectively. In the multivariate logistic regression models adjusted for medical history, body mass index, lipid profiles, insulin resistance and BMD in men, the higher concentration of ucOC and higher OCR showed significant association with coronary calcification (CACS > 0). CONCLUSION: Higher ucOC concentration was associated with coronary artery calcification independent of conventional cardiovascular risk factors and BMD in men.
CONTEXT: Osteocalcin is associated with energy metabolism and atherosclerosis, besides bone metabolism. However, the association between osteocalcin or its undercarboxylated form (ucOC) and coronary artery calcification is controversial. OBJECTIVE: To evaluate the relationship between coronary artery calcium score (CACS) and the concentration of serum osteocalcin and ucOC. DESIGN: Cross-sectional. PATIENTS: A total of 162 subjects (114 men and 48 women) with no angina symptom. MEASUREMENTS: Serum analyses included glucose, insulin and lipid profiles as well as osteocalcin and ucOC. Bone mineral density (BMD) was measured by dual X-ray absorptiometry. CACS was measured using multidetector computed tomography and categorized into CACS = 0 and CACS > 0. RESULTS: The mean osteocalcin concentration in men was 15·6 ± 4·2 for CACS = 0 group and 14·1 ± 4·0 for CACS > 0 group, respectively (P = 0·050). In women, the osteocalcin concentration, ucOC concentration and ucOC to osteocalcin ratio (OCR) were not different between the CACS groups. However, the concentrations of osteocalcin and ucOC were significantly lower in women with hypertension or diabetes than those without, respectively. In the multivariate logistic regression models adjusted for medical history, body mass index, lipid profiles, insulin resistance and BMD in men, the higher concentration of ucOC and higher OCR showed significant association with coronary calcification (CACS > 0). CONCLUSION: Higher ucOC concentration was associated with coronary artery calcification independent of conventional cardiovascular risk factors and BMD in men.
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