| Literature DB >> 25868130 |
Guillermo M Zúñiga-González1, Belinda C Gómez-Meda2, Ana L Zamora-Perez3, María A Martínez-González4, Ilse A Muñoz de Haro4, Adhoksaja E Pérez-Navarro4, Juan Armendáriz-Borunda2, Martha P Gallegos-Arreola5.
Abstract
Pregnant hairless rat dams were exposed to ultraviolet-A light (UVA) to induce micronucleated erythrocytes (MNE) in their fetuses. The control group was exposed to conventional light; the experimental groups were exposed to UVA (365nm) during gestational days 16-21. In some cases, ascorbic acid (Asc) was administered in the drinking water from gestational day 15 until delivery. Dams were sampled at 48-h intervals during gestation, from day 16 until delivery. Blood was also obtained from neonates at birth; MNE, micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) were scored. Increased MNE and MNPCE were observed in neonates born to mothers exposed to UVA for 40, 80 or 160min, compared to the control group. Asc treatment reduced MNE and MNPCE induction.Entities:
Keywords: Antioxidant; Ascorbic acid; Fetus; Genotoxicity; Pregnancy; Ultraviolet light
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Year: 2015 PMID： 25868130 DOI： 10.1016/j.mrgentox.2015.03.013
Source DB: PubMed Journal: Mutat Res Genet Toxicol Environ Mutagen ISSN： 1383-5718 Impact factor: 2.873