Y Ko1, Y-M Lee2, H-Y Lee2, Y S Lee2, J-W Song3, G-Y Hong4, M-Y Kim2, H-K Lee2, S J Choi5, E-J Shim6. 1. Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. 2. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. 3. Division of Pulmonary Medicine, CHA University School of Medicine, Gumi CHA Hospital, Gumi, Republic of Korea. 4. Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Dankook University Hospital, Cheonan, Republic of Korea. 5. Department of Radiology, Inje University College of Medicine, Busan, Republic of Korea. 6. Department of Pharmacology and Pharmaco Genomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
Abstract
OBJECTIVE: To evaluate changes in lung function in individuals before and after treatment for pulmonary tuberculosis (PTB) in relation to extent of disease. DESIGN: Using a retrospective cohort design, changes in and predictors of lung function were evaluated. RESULTS: A total of 41 patients were included in the final analysis. The median decline in annualised forced expiratory volume in 1 sec (FEV1) was 180.0 ml/year (95%CI 118.9-356.1) in advanced PTB and 94.7 ml/year (95%CI 33.4-147.3) in localised PTB (ΔFEV1% predicted/year 9.4%, 95%CI 4.4-14.0 vs. 3.8%, 95%CI 1.8-6.2). The median decline in annualised forced vital capacity (FVC) was 309.6 ml/year (95%CI 137.0-359.0) in advanced PTB and 101.1 ml/year (95%CI 30.3-219.6) in localised PTB (ΔFVC % predicted/year 7.3%, 95%CI 5.3-12.3 vs. 2.9%, 95%CI 0.9-6.5). CONCLUSIONS: As the sample size of our study was small, the conclusions could be biased. Nevertheless, our findings show that PTB causes a significant decline in lung function even in localised PTB, whereas advanced PTB was associated with excessive or even higher decline. This study suggests that early diagnosis and treatment of PTB is needed to preserve lung function.
OBJECTIVE: To evaluate changes in lung function in individuals before and after treatment for pulmonary tuberculosis (PTB) in relation to extent of disease. DESIGN: Using a retrospective cohort design, changes in and predictors of lung function were evaluated. RESULTS: A total of 41 patients were included in the final analysis. The median decline in annualised forced expiratory volume in 1 sec (FEV1) was 180.0 ml/year (95%CI 118.9-356.1) in advanced PTB and 94.7 ml/year (95%CI 33.4-147.3) in localised PTB (ΔFEV1% predicted/year 9.4%, 95%CI 4.4-14.0 vs. 3.8%, 95%CI 1.8-6.2). The median decline in annualised forced vital capacity (FVC) was 309.6 ml/year (95%CI 137.0-359.0) in advanced PTB and 101.1 ml/year (95%CI 30.3-219.6) in localised PTB (ΔFVC % predicted/year 7.3%, 95%CI 5.3-12.3 vs. 2.9%, 95%CI 0.9-6.5). CONCLUSIONS: As the sample size of our study was small, the conclusions could be biased. Nevertheless, our findings show that PTB causes a significant decline in lung function even in localised PTB, whereas advanced PTB was associated with excessive or even higher decline. This study suggests that early diagnosis and treatment of PTB is needed to preserve lung function.
Authors: Brian W Allwood; Elizna Maasdorp; Grace J Kim; Christopher B Cooper; Jonathan Goldin; Richard N van Zyl-Smit; Eric D Bateman; Rodney Dawson Journal: Int J Chron Obstruct Pulmon Dis Date: 2020-05-11
Authors: Akshay N Gupte; Michelle L Wong; Reginah Msandiwa; Grace L Barnes; Jonathan Golub; Richard E Chaisson; Christopher J Hoffmann; Neil A Martinson Journal: PLoS One Date: 2017-09-13 Impact factor: 3.240
Authors: Sanne C van Kampen; Amanda Wanner; Miles Edwards; Anthony D Harries; Bruce J Kirenga; Jeremiah Chakaya; Rupert Jones Journal: BMJ Glob Health Date: 2018-07-23