Literature DB >> 25867944

Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction.

F Pertusati1, C McGuigan.   

Abstract

The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25867944     DOI： 10.1039/c5cc00448a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction.

Authors:  Hanglu Ying; Jie Yao; Fan Wu; Yufen Zhao; Feng Ni
Journal:  RSC Adv       Date:  2022-04-29       Impact factor: 4.036

Review 2.  Phosphoramidates and phosphonamidates (ProTides) with antiviral activity.

Authors:  Magdalena Slusarczyk; Michaela Serpi; Fabrizio Pertusati
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

3.  Treating a Global Health Crisis with a Dose of Synthetic Chemistry.

Authors:  Melissa A Hardy; Brandon A Wright; J Logan Bachman; Timothy B Boit; Hannah M S Haley; Rachel R Knapp; Robert F Lusi; Taku Okada; Veronica Tona; Neil K Garg; Richmond Sarpong
Journal:  ACS Cent Sci       Date:  2020-06-30       Impact factor: 14.553

4.  Microwave-assisted organic synthesis of nucleoside ProTide analogues.

Authors:  Cinzia Bordoni; Cecilia Maria Cima; Elisa Azzali; Gabriele Costantino; Andrea Brancale
Journal:  RSC Adv       Date:  2019-06-27       Impact factor: 4.036

5.  Potent double prodrug forms of synthetic phosphoantigens.

Authors:  Nyema M Harmon; Xueting Huang; Megan A Schladetsch; Chia-Hung Christine Hsiao; Andrew J Wiemer; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2020-07-29       Impact factor: 3.461
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.