| Literature DB >> 25867463 |
Jun-Sang Sunwoo1, Soon-Tae Lee1, Jung-Ick Byun1, Jangsup Moon1, Jung-Won Shin2, Da-Eun Jeong3, Gun-Hee Lee4, Seong Ho Jeong5, Yong-Won Shin1, Keun-Hwa Jung1, Doo Young Lee1, Daejong Jeon1, Ki-Young Jung1, Manho Kim6, Sang Kun Lee1, Kon Chu7.
Abstract
Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.Entities:
Keywords: CASPR2; Epilepsy; Immunotherapy; Neuromyotonia
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Year: 2015 PMID： 25867463 DOI： 10.1016/j.jneuroim.2015.03.005
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478