| Literature DB >> 25867461 |
Mohammad Sajad Emami Aleagha1, Bahaadin Siroos2, Mona Ahmadi2, Mohammad Balood1, Alireza Palangi1, Afsaneh Nazari Haghighi2, Mohammad Hossein Harirchian3.
Abstract
Recent investigations support that an anti-aging protein, namely Klotho, protects neurons against the oxidative stress and demyelination. We evaluated the protein concentration of Klotho and total anti-oxidant capacity (TAC) in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS). Klotho concentration and TAC were significantly lower in patients as compared to controls. Klotho values showed a significant negative correlation with expanded disability status scale (EDSS). Moreover, a significantly positive correlation between TAC levels and Klotho concentrations was detected. Klotho may play an important role in the pathogenesis of MS, at least in part, through the regulation of redox system.Entities:
Keywords: FRAP assay; Klotho; Multiple sclerosis; Redox system
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Year: 2015 PMID： 25867461 DOI： 10.1016/j.jneuroim.2015.02.004
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478