Qiaojuan Guo1,2,3, Xiaofei Cui1,2,3, Shaojun Lin1,2,3, Jin Lin1,3, Jianji Pan1,2,3. 1. Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China. 2. Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian, China. 3. Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
Abstract
BACKGROUND: The purpose of this study was to evaluate the treatment outcomes and toxicities of intensity-modulated radiation therapy (IMRT) for children and adolescents with locoregionally advanced nasopharyngeal carcinoma (NPC). METHODS: Ninety-five patients of <25 years old in locoregionally advanced NPC (stage III-IVB) were analyzed. All were given neoadjuvant chemotherapy followed by IMRT with or without concurrent chemotherapy/adjuvant chemotherapy. RESULTS: The 4-year overall survival (OS), locoregional relapse-free survival, progression-free survival (PFS), and distant metastasis-free survival (DMFS) were 90.8%, 94.9%, 79.1%, and 84.0%, respectively. N classification was the only significant predicting factor for OS, PFS, and DMFS, with the p value of .017, .015, and 0.054, respectively. The main long-term complications were xerostomia, hearing impairment, and neck fibrosis. CONCLUSION: Neoadjuvant chemotherapy followed by IMRT with or without concurrent/adjuvant chemotherapy produced a superb treatment outcome in children and adolescents with stage III to IVB disease. Distant metastasis was the main failure. More effective treatment strategies are urgently needed to further improve the long-term survival.
BACKGROUND: The purpose of this study was to evaluate the treatment outcomes and toxicities of intensity-modulated radiation therapy (IMRT) for children and adolescents with locoregionally advanced nasopharyngeal carcinoma (NPC). METHODS: Ninety-five patients of <25 years old in locoregionally advanced NPC (stage III-IVB) were analyzed. All were given neoadjuvant chemotherapy followed by IMRT with or without concurrent chemotherapy/adjuvant chemotherapy. RESULTS: The 4-year overall survival (OS), locoregional relapse-free survival, progression-free survival (PFS), and distant metastasis-free survival (DMFS) were 90.8%, 94.9%, 79.1%, and 84.0%, respectively. N classification was the only significant predicting factor for OS, PFS, and DMFS, with the p value of .017, .015, and 0.054, respectively. The main long-term complications were xerostomia, hearing impairment, and neck fibrosis. CONCLUSION: Neoadjuvant chemotherapy followed by IMRT with or without concurrent/adjuvant chemotherapy produced a superb treatment outcome in children and adolescents with stage III to IVB disease. Distant metastasis was the main failure. More effective treatment strategies are urgently needed to further improve the long-term survival.
Authors: Anaïs Jouin; Sylvie Helfre; Stéphanie Bolle; Line Claude; Anne Laprie; Emilie Bogart; Céline Vigneron; Hélène Potet; Anne Ducassou; Audrey Claren; François Georges Riet; Marie Pierre Castex; Cécile Faure-Conter; Brice Fresneau; Anne Sophie Defachelles; Daniel Orbach Journal: Strahlenther Onkol Date: 2019-04-08 Impact factor: 3.621
Authors: Alejandro González-Motta; Garvin González; Yurany Bermudéz; Maria C Maldonado; Javier M Castañeda; David Lopéz; Martha Cotes-Mestre Journal: Cureus Date: 2016-02-15