Literature DB >> 25866154

Controlling epileptiform activity with organic electronic ion pumps.

Adam Williamson1,2, Jonathan Rivnay3, Loïg Kergoat4, Amanda Jonsson4, Sahika Inal3, Ilke Uguz3, Marc Ferro3, Anton Ivanov1,2, Theresia Arbring Sjöström4, Daniel T Simon4, Magnus Berggren4, George G Malliaras3, Christophe Bernard1,2.   

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  PEDOT:PSS; neuroengineering; organic bioelectronics; organic electronic ion pumps

Mesh：

Substances：

Year:  2015        PMID： 25866154     DOI： 10.1002/adma.201500482

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


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