Zachary M Sellers1, Lori McGlocklin2, Andrea Brasch2. 1. College of Medicine, University of Illinois, Urbana-Champaign, Urbana, IL, USA. Electronic address: zsellers@stanford.edu. 2. Heart and Cardiovascular Center, Carle Foundation Hospital, Urbana, IL, USA.
Abstract
BACKGROUND: CFTR is expressed in cardiac myocytes. In mice, lack of CFTR alters cardiomyocyte contraction and Ca2+ signaling, and decreases cardiac reserve. We undertook a pilot study evaluating left ventricular (LV) function in CF patients using strain and strain rate echocardiography. METHODS: Echocardiography with tissue Doppler and strain and strain rate imaging were performed in 8 CF adults following pulmonary function tests. Results were compared to literature values obtained in healthy subjects. RESULTS: All CF individuals had normal LV ejection fractions. In contrast, 50% of men and 100% of women with CF had decreased LV systolic strain. Strain rates were significantly decreased in 100% of CF individuals. RV function was normal and LV function did not correlate with lung function. CONCLUSIONS: Strain and strain rate echocardiography identified LV systolic abnormalities in CF individuals not detected by conventional echocardiography. We propose that this echocardiography modality may identify subclinical cardiac dysfunction in CF.
BACKGROUND:CFTR is expressed in cardiac myocytes. In mice, lack of CFTR alters cardiomyocyte contraction and Ca2+ signaling, and decreases cardiac reserve. We undertook a pilot study evaluating left ventricular (LV) function in CF patients using strain and strain rate echocardiography. METHODS: Echocardiography with tissue Doppler and strain and strain rate imaging were performed in 8 CF adults following pulmonary function tests. Results were compared to literature values obtained in healthy subjects. RESULTS: All CF individuals had normal LV ejection fractions. In contrast, 50% of men and 100% of women with CF had decreased LV systolic strain. Strain rates were significantly decreased in 100% of CF individuals. RV function was normal and LV function did not correlate with lung function. CONCLUSIONS: Strain and strain rate echocardiography identified LV systolic abnormalities in CF individuals not detected by conventional echocardiography. We propose that this echocardiography modality may identify subclinical cardiac dysfunction in CF.
Authors: Erik H Van Iterson; Courtney M Wheatley; Sarah E Baker; Wayne J Morgan; Eric M Snyder Journal: Heart Lung Date: 2016-04-01 Impact factor: 2.210
Authors: Erik H Van Iterson; Courtney M Wheatley; Sarah E Baker; Thomas P Olson; Wayne J Morgan; Eric M Snyder Journal: PLoS One Date: 2016-12-20 Impact factor: 3.240