OBJECTIVE: Human brown adipose tissue (BAT) activity has been typically evaluated by (18) F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed tomography (CT). However, FDG-PET/CT has serious limitations (e.g., radiation and cold exposure). This study evaluated BAT density using near-infrared time-resolved spectroscopy (NIRTRS ), a simple and noninvasive method of measuring the indices of tissue hemoglobin concentration [total-Hb] and mitochondrial density (µs '). METHODS: The NIRTRS parameters at 760, 800, and 830 nm in the supraclavicular region potentially containing BAT were evaluated. First, the NIRTRS parameters were compared at 27 °C and during a 2-h cold exposure (19 °C) in 18 men. Then, NIRTRS parameters at 27 °C were compared with mean standardized uptake values (SUVmean ) assessed by FDG-PET/CT after the 2-h cold exposure (19 °C) in 29 men. RESULTS: There was no significant difference between the NIRTRS parameters at 27 °C and 19°C. The [total-Hb] and µs ' were significantly correlated to SUVmean (r = 0.73 and r = 0.64, respectively). A receiver operating characteristic analysis revealed that the sensitivity (75.0-82.4%), specificity (91.7-100%), and accuracy (82.8-86.2%) of the NIRTRS parameters were all good to determine the NIRTRS reliability. CONCLUSIONS: Our novel NIRTRS method is noninvasive and simple and can reliably assess human BAT density in the supraclavicular region.
OBJECTIVE:Human brown adipose tissue (BAT) activity has been typically evaluated by (18) F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed tomography (CT). However, FDG-PET/CT has serious limitations (e.g., radiation and cold exposure). This study evaluated BAT density using near-infrared time-resolved spectroscopy (NIRTRS ), a simple and noninvasive method of measuring the indices of tissue hemoglobin concentration [total-Hb] and mitochondrial density (µs '). METHODS: The NIRTRS parameters at 760, 800, and 830 nm in the supraclavicular region potentially containing BAT were evaluated. First, the NIRTRS parameters were compared at 27 °C and during a 2-h cold exposure (19 °C) in 18 men. Then, NIRTRS parameters at 27 °C were compared with mean standardized uptake values (SUVmean ) assessed by FDG-PET/CT after the 2-h cold exposure (19 °C) in 29 men. RESULTS: There was no significant difference between the NIRTRS parameters at 27 °C and 19°C. The [total-Hb] and µs ' were significantly correlated to SUVmean (r = 0.73 and r = 0.64, respectively). A receiver operating characteristic analysis revealed that the sensitivity (75.0-82.4%), specificity (91.7-100%), and accuracy (82.8-86.2%) of the NIRTRS parameters were all good to determine the NIRTRS reliability. CONCLUSIONS: Our novel NIRTRS method is noninvasive and simple and can reliably assess human BAT density in the supraclavicular region.
Authors: Francisco M Acosta; Jörn Berchem; Borja Martinez-Tellez; Guillermo Sanchez-Delgado; Juan M A Alcantara; Lourdes Ortiz-Alvarez; Takafumi Hamaoka; Jonatan R Ruiz Journal: Mol Imaging Biol Date: 2019-04 Impact factor: 3.488
Authors: Sergios Gatidis; Holger Schmidt; Christina A Pfannenberg; Konstantin Nikolaou; Fritz Schick; Nina F Schwenzer Journal: PLoS One Date: 2016-03-11 Impact factor: 3.240