Literature DB >> 25865647

Evaluation of Initial Telomere Length and Changes after Transplantation in Adult Double-Unit Cord Blood Transplant Recipients.

Beth Ashbridge1, Ahmet Zehir1, Marissa Lubin2, Juliet N Barker3, Malcolm A S Moore1.   

Abstract

Cord blood (CB) leukocytes have inherent telomere length (TL) variation, and CB hematopoietic stem cells (HSC) can maintain high telomerase levels preventing telomere attrition in vitro. We evaluated TL changes in 13 adult double-unit CB transplant (CBT) recipients. In the 26 units, we observed a marked variation in CB TL at thaw (median, 9.99 kilobases [kb]; range, 6.85 to 13.5). All 13 patients engrafted. Of 11 engrafting with 1 unit, there was no correlation between unit dominance and TL (mean dominant unit TL, 8.84 kb ± 1.76; mean nonengrafting unit TL, 10.3 kb ± 1.81; P = .77). Serial measurements of TL up to 1 year after CBT demonstrated an overall mean 3.04 kb ± .16 TL decrease with only 1 patient exhibiting telomere maintenance. In summary, initial TL does not predict CB unit dominance. Moreover, our analysis suggests neonatal hematopoiesis makes a transition to an HSC characterized by changes in average TL and potentially low telomerase asymmetric cell division in adult CBT recipients. Further investigation of alterations in telomere length and its clinical implications after transplantation of this observation are indicated.
Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Allogeneic transplantation; Cord blood; Telomere length

Mesh：

Substances：

Year:  2015        PMID： 25865647      PMCID： PMC4466009          DOI： 10.1016/j.bbmt.2015.04.006

Source DB:  PubMed          Journal:  Biol Blood Marrow Transplant        ISSN： 1083-8791            Impact factor:   5.742


  7 in total

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Journal:  Biol Blood Marrow Transplant       Date:  2013-02-14       Impact factor: 5.742

2.  A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation.

Authors:  Doris M Ponce; Craig Sauter; Sean Devlin; Marissa Lubin; Anne Marie Gonzales; Nancy A Kernan; Andromachi Scaradavou; Sergio Giralt; Jenna D Goldberg; Guenther Koehne; Miguel A Perales; James W Young; Hugo Castro-Malaspina; Ann Jakubowski; Esperanza B Papadopoulos; Juliet N Barker
Journal:  Biol Blood Marrow Transplant       Date:  2013-02-14       Impact factor: 5.742

3.  Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts.

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Journal:  Blood       Date:  2010-12-13       Impact factor: 22.113

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5.  Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

Authors:  H Vaziri; W Dragowska; R C Allsopp; T E Thomas; C B Harley; P M Lansdorp
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

6.  Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.

Authors:  Juliet N Barker; Daniel J Weisdorf; Todd E DeFor; Bruce R Blazar; Philip B McGlave; Jeffrey S Miller; Catherine M Verfaillie; John E Wagner
Journal:  Blood       Date:  2004-10-05       Impact factor: 22.113

7.  A "no-wash" albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactions.

Authors:  Juliet N Barker; Michelle Abboud; Robert D Rice; Rebecca Hawke; Allison Schaible; Glenn Heller; Vincent La Russa; Andromachi Scaradavou
Journal:  Biol Blood Marrow Transplant       Date:  2009-09-25       Impact factor: 5.742
  7 in total
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1.  The Effect of Cancer Treatments on Telomere Length: A Systematic Review of the Literature.

Authors:  Lisa Gallicchio; Shahinaz M Gadalla; John D Murphy; Naoko I Simonds
Journal:  J Natl Cancer Inst       Date:  2018-10-01       Impact factor: 13.506

2.  Decoupling blood telomere length from age in recipients of allogeneic hematopoietic cell transplant in the BMT-CTN 1202.

Authors:  Tsung-Po Lai; Simon Verhulst; Casey L Dagnall; Amy Hutchinson; Stephen R Spellman; Alan Howard; Hormuzd A Katki; John E Levine; Wael Saber; Abraham Aviv; Shahinaz M Gadalla
Journal:  Front Immunol       Date:  2022-10-03       Impact factor: 8.786
  2 in total

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