CONTEXT: There is a need to improve stroke care through the prompt identification of stroke patients at increased risk of an adverse outcome. OBJECTIVE: To evaluate the prognostic value of copeptin in patients with stroke. METHODS: We systematically searched PubMed and Embase for relevant studies. Poor outcome and mortality were analyzed. RESULTS: Twelve studies, containing 2682 patients, were included. Pooled analysis showed that copeptin is an independent prognostic marker of poor outcome after acute stroke and there is a borderline effect of copeptin in predicting mortality after acute stroke. CONCLUSIONS: Copeptin is an independent predictor of poor outcome and mortality for patients with acute stroke.
CONTEXT: There is a need to improve stroke care through the prompt identification of strokepatients at increased risk of an adverse outcome. OBJECTIVE: To evaluate the prognostic value of copeptin in patients with stroke. METHODS: We systematically searched PubMed and Embase for relevant studies. Poor outcome and mortality were analyzed. RESULTS: Twelve studies, containing 2682 patients, were included. Pooled analysis showed that copeptin is an independent prognostic marker of poor outcome after acute stroke and there is a borderline effect of copeptin in predicting mortality after acute stroke. CONCLUSIONS:Copeptin is an independent predictor of poor outcome and mortality for patients with acute stroke.