| Literature DB >> 25865552 |
Matthew Mason1, Meredith Giuliani1, Shao Hui Huang1, Wei Xu2, Andrew Hope1, John Kim1, Andrew Bayley1, B C John Cho1, David Goldstein3, Raymond W Jang4, Bayardo Perez Ordonez5, Sandra Wajstaub6, John Waldron1, Robert Dinniwell1, Brian O'Sullivan1, Jolie Ringash1.
Abstract
Head-and-neck small cell carcinoma (HN-SmCC) is a rare entity and there is limited data to support management decisions. The role of prophylactic cranial irradiation (PCI) remains controversial. A retrospective review of 21 consecutive HN-SmCCs was performed. No case received PCI. The 2-year overall survival, local, regional and distant control rates were 65%, 94%, 88%, and 76% respectively. Despite no patient receiving PCI, brain metastases were uncommon (n=2) and routine use of PCI is not justified in this population.Entities:
Keywords: Brain metastases; Chemoradiotherapy; Head and neck carcinoma; IMRT; Local failure; Neurocognition; Patterns of failure; Prophylactic cranial irradiation; Small cell carcinoma; Whole brain radiation
Mesh：
Year: 2015 PMID： 25865552 DOI： 10.1016/j.oraloncology.2015.03.014
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337