AIM: The objective of this study was to evaluate the effects of T4 phage on adsorption and replication of human adenovirus (HAdV). MATERIALS & METHODS: Experiments were performed on cell lines A549 and HEK-293. Intracellular HAdV virions were released and titrated by Reed-Muench method. RESULTS: T4 significantly (p < 0.05) inhibited both the adsorption of HAdV and viral replication in a dose-dependent manner. Mean reductions in HAdV titer were within the range 0.634-2.12 and 0.238-1.88 log10 TCID50/ml for HAdV adsorption and replication, respectively. CONCLUSION: T4 phage can inhibit infections by HAdV-5 of target cells. Our results suggest that T4 might be considered a novel agent against HAdV and possibly other pathogenic viruses. Potential antiviral effects of other phages should also be investigated.
AIM: The objective of this study was to evaluate the effects of T4 phage on adsorption and replication of human adenovirus (HAdV). MATERIALS & METHODS: Experiments were performed on cell lines A549 and HEK-293. Intracellular HAdV virions were released and titrated by Reed-Muench method. RESULTS: T4 significantly (p < 0.05) inhibited both the adsorption of HAdV and viral replication in a dose-dependent manner. Mean reductions in HAdV titer were within the range 0.634-2.12 and 0.238-1.88 log10 TCID50/ml for HAdV adsorption and replication, respectively. CONCLUSION: T4 phage can inhibit infections by HAdV-5 of target cells. Our results suggest that T4 might be considered a novel agent against HAdV and possibly other pathogenic viruses. Potential antiviral effects of other phages should also be investigated.
Authors: Andrzej Górski; Ryszard Międzybrodzki; Beata Weber-Dąbrowska; Wojciech Fortuna; Sławomir Letkiewicz; Paweł Rogóż; Ewa Jończyk-Matysiak; Krystyna Dąbrowska; Joanna Majewska; Jan Borysowski Journal: Front Microbiol Date: 2016-09-26 Impact factor: 5.640
Authors: Ryszard Międzybrodzki; Marlena Kłak; Ewa Jończyk-Matysiak; Barbara Bubak; Anna Wójcik; Marta Kaszowska; Beata Weber-Dąbrowska; Małgorzata Łobocka; Andrzej Górski Journal: Front Microbiol Date: 2017-03-23 Impact factor: 5.640
Authors: A Górski; E Jończyk-Matysiak; M Łusiak-Szelachowska; B Weber-Dąbrowska; R Międzybrodzki; J Borysowski Journal: Clin Exp Immunol Date: 2018-01-23 Impact factor: 4.330
Authors: Jonas D Van Belleghem; Krystyna Dąbrowska; Mario Vaneechoutte; Jeremy J Barr; Paul L Bollyky Journal: Viruses Date: 2018-12-25 Impact factor: 5.048
Authors: Andrzej Górski; Paul L Bollyky; Maciej Przybylski; Jan Borysowski; Ryszard Międzybrodzki; Ewa Jończyk-Matysiak; Beata Weber-Dąbrowska Journal: Front Microbiol Date: 2019-01-09 Impact factor: 5.640