PURPOSE: To evaluate the Th1/Th2/Th17 cytokine levels in plasma and gingival crevicular fluid (GCF) from chronic periodontitis patients and healthy controls. METHODS: The concentration of interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, TNF, and IFN-γ were determined using a flow cytometric multiplex immunoassay (CBA), and was compared between the periodontitis group and the healthy group. Spearman rho coefficient was used to correlate cytokines in GCF in the periodontitis group and the healthy group, respectively. RESULTS: Comparisons of two groups of Th1/Th2/Th17 cytokine levels in plasma and GCF showed no statistically significant differences (P > 0.05), except Th17 (IL-17) level in plasma that was higher in the periodontitis group than the healthy group (P < 0.05). A stronger correlation between IL-17/IL-4 and IL-17/IL-10 was observed in periodontitis patients than in healthy controls.
PURPOSE: To evaluate the Th1/Th2/Th17 cytokine levels in plasma and gingival crevicular fluid (GCF) from chronic periodontitispatients and healthy controls. METHODS: The concentration of interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, TNF, and IFN-γ were determined using a flow cytometric multiplex immunoassay (CBA), and was compared between the periodontitis group and the healthy group. Spearman rho coefficient was used to correlate cytokines in GCF in the periodontitis group and the healthy group, respectively. RESULTS: Comparisons of two groups of Th1/Th2/Th17 cytokine levels in plasma and GCF showed no statistically significant differences (P > 0.05), except Th17 (IL-17) level in plasma that was higher in the periodontitis group than the healthy group (P < 0.05). A stronger correlation between IL-17/IL-4 and IL-17/IL-10 was observed in periodontitispatients than in healthy controls.
Authors: P C Carvalho-Filho; I S Gomes-Filho; R Meyer; T Olczak; M T Xavier; S C Trindade Journal: Mediators Inflamm Date: 2016-06-15 Impact factor: 4.711
Authors: Christian R Jarry; Elizabeth F Martinez; Daiane C Peruzzo; Vanessa Carregaro; Laís A Sacramento; Vera C Araújo; M Neale Weitzmann; Marcelo H Napimoga Journal: Mol Med Rep Date: 2016-03-24 Impact factor: 2.952
Authors: Dorin Nicolae Gheorghe; Liliana Foia; Vasilica Toma; Amelia Surdu; Elena Herascu; Dora Maria Popescu; Petra Surlin; Cristin Constantin Vere; Ion Rogoveanu Journal: J Immunol Res Date: 2018-03-13 Impact factor: 4.818