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Literature DB >> 25863241

Hold the salt: vasopressor role for BDNF.

Abstract

In a recent publication in Neuron, Choe et al. (2015) demonstrate that brain-derived neurotrophic factor (BDNF) signaling mediates salt-induced blood pressure elevation by increasing the excitability of hypothalamic vasopressin-secreting neurons. These findings suggest complex roles for BDNF in adaptive cardiovascular responses to physiological challenges and in the pathogenesis of hypertension.

Entities: Chemical Disease Gene Species

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Year: 2015 PMID： 25863241 PMCID： PMC5840492 DOI： 10.1016/j.cmet.2015.03.015

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

10 in total

1. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation.

Authors: Ning Feng; Sabine Huke; Guangshuo Zhu; Carlo G Tocchetti; Sa Shi; Takeshi Aiba; Nina Kaludercic; Donald B Hoover; Sarah E Beck; Joseph L Mankowski; Gordon F Tomaselli; Donald M Bers; David A Kass; Nazareno Paolocci
Journal: Proc Natl Acad Sci U S A Date: 2015-01-12 Impact factor: 11.205

Review 2. Prehypertension--prevalence, health risks, and management strategies.

Authors: Brent M Egan; Sean Stevens-Fabry
Journal: Nat Rev Cardiol Date: 2015-02-17 Impact factor: 32.419

3. Chronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat.

Authors: Jeong Sook Kim; Woong Bin Kim; Young-Beom Kim; Yeon Lee; Yoon Sik Kim; Feng-Yan Shen; Seung Won Lee; Dawon Park; Hee-Joo Choi; Jinyoung Hur; Joong Jean Park; Hee Chul Han; Christopher S Colwell; Young-Wuk Cho; Yang In Kim
Journal: J Neurosci Date: 2011-09-14 Impact factor: 6.167

Review 4. Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence.

Authors: Mark P Mattson
Journal: Ageing Res Rev Date: 2015-01-07 Impact factor: 10.895

5. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Authors: Katrina Y Choe; Su Y Han; Perrine Gaub; Brent Shell; Daniel L Voisin; Blayne A Knapp; Philip A Barker; Colin H Brown; J Thomas Cunningham; Charles W Bourque
Journal: Neuron Date: 2015-01-22 Impact factor: 17.173

Review 6. BDNF mediates adaptive brain and body responses to energetic challenges.

Authors: Krisztina Marosi; Mark P Mattson
Journal: Trends Endocrinol Metab Date: 2013-12-19 Impact factor: 12.015

7. Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

Authors: Claudio Rivera; Juha Voipio; Judith Thomas-Crusells; Hong Li; Zsuzsa Emri; Sampsa Sipilä; John A Payne; Liliana Minichiello; Mart Saarma; Kai Kaila
Journal: J Neurosci Date: 2004-05-12 Impact factor: 6.167

8. Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability.

Authors: Ruiqian Wan; Letitia A Weigand; Ryan Bateman; Kathleen Griffioen; David Mendelowitz; Mark P Mattson
Journal: J Neurochem Date: 2014-02-10 Impact factor: 5.372

9. Molecular and neural bases underlying roles of BDNF in the control of body weight.

Authors: Filip Vanevski; Baoji Xu
Journal: Front Neurosci Date: 2013-03-21 Impact factor: 4.677

Review 10. Stress-induced plasticity of GABAergic inhibition.

Authors: Jamie Maguire
Journal: Front Cell Neurosci Date: 2014-06-06 Impact factor: 5.505