Thomas G O'Connor1, Hongyue Wang2, Jan A Moynihan3, Peter A Wyman3, Jennifer Carnahan2, Gerry Lofthus4, Sally A Quataert5, Melissa Bowman6, Anne S Burke7, Mary T Caserta8. 1. Wynne Center for Family Research, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States; Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. Electronic address: Tom_OConnor@URMC.Rochester.edu. 2. Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. 3. Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. 4. Department of Medicine, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. 5. Department of Microbiology and Immunology, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. 6. Department of Pediatrics, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. 7. Department of Psychology, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642, United States. 8. Department of Pediatrics, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, United States. Electronic address: Mary_Caserta@URMC.Rochester.edu.
Abstract
BACKGROUND: Quality of the parent-child relationship is a robust predictor of behavioral and emotional health for children and adolescents; the application to physical health is less clear. METHODS: We investigated the links between observed parent-child relationship quality in an interaction task and antibody response to meningococcal conjugate vaccine in a longitudinal study of 164 ambulatory 10-11 year-old children; additional analyses examine associations with cortisol reactivity, BMI, and somatic illness. RESULTS: Observed Negative/Conflict behavior in the interaction task predicted a less robust antibody response to meningococcal serotype C vaccine in the child over a 6 month-period, after controlling for socio-economic and other covariates. Observer rated interaction conflict also predicted increased cortisol reactivity following the interaction task and higher BMI, but these factors did not account for the link between relationship quality and antibody response. CONCLUSIONS: The results begin to document the degree to which a major source of child stress exposure, parent-child relationship conflict, is associated with altered immune system development in children, and may constitute an important public health consideration.
BACKGROUND: Quality of the parent-child relationship is a robust predictor of behavioral and emotional health for children and adolescents; the application to physical health is less clear. METHODS: We investigated the links between observed parent-child relationship quality in an interaction task and antibody response to meningococcal conjugate vaccine in a longitudinal study of 164 ambulatory 10-11 year-old children; additional analyses examine associations with cortisol reactivity, BMI, and somatic illness. RESULTS: Observed Negative/Conflict behavior in the interaction task predicted a less robust antibody response to meningococcal serotype C vaccine in the child over a 6 month-period, after controlling for socio-economic and other covariates. Observer rated interaction conflict also predicted increased cortisol reactivity following the interaction task and higher BMI, but these factors did not account for the link between relationship quality and antibody response. CONCLUSIONS: The results begin to document the degree to which a major source of child stress exposure, parent-child relationship conflict, is associated with altered immune system development in children, and may constitute an important public health consideration.
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