Shazia Mahmood1, Khanh Vu1, Patricia Tai2, Kurian Joseph3, Rashmi Koul4, Arbind Dubey4, Edward Yu5. 1. Radiation Oncology Department, Allan Blair Cancer Center, Regina, SK, Canada. 2. Radiation Oncology Department, Allan Blair Cancer Center, Regina, SK, Canada patricia.tai@saskcancer.ca. 3. Radiation Oncology Department, Cross Cancer Institute, Edmonton, AB, Canada. 4. Radiation Oncology Program, Winnipeg, MB, Canada. 5. University of Western Ontario, Radiation Oncology Department, London Health Science Center, London, ON, Canada.
Abstract
BACKGROUND: The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to shared etiologic exposures. PATIENTS AND METHODS: This article focuses on radiation-induced malignancies with illustrative cases of thyroid, rectal cancer and sarcoma. RESULTS: The detection and management of radiation-induced malignancies of some case scenarios are presented. Second malignancies are detected within previous radiation field and the time intervals from previous tumor vary from 8 to 21 years. CONCLUSION: Clinicians should aim to reduce radiation-induced malignancies by careful selection of patients and radiation techniques before radiotherapy. Subsequent vigilant follow-up and investigations can detect these radiation-induced malignancies early and, hence, result in successful treatment. Copyright
BACKGROUND: The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to shared etiologic exposures. PATIENTS AND METHODS: This article focuses on radiation-induced malignancies with illustrative cases of thyroid, rectal cancer and sarcoma. RESULTS: The detection and management of radiation-induced malignancies of some case scenarios are presented. Second malignancies are detected within previous radiation field and the time intervals from previous tumor vary from 8 to 21 years. CONCLUSION: Clinicians should aim to reduce radiation-induced malignancies by careful selection of patients and radiation techniques before radiotherapy. Subsequent vigilant follow-up and investigations can detect these radiation-induced malignancies early and, hence, result in successful treatment. Copyright
Authors: Georgios E Christakopoulos; Georgios Christopoulos; Dimitri Karmpaliotis; Khaldoon Alaswad; Robert W Yeh; Farouc A Jaffer; Michael R Wyman; William L Lombardi; Muhammad Nauman J Tarar; J Aaron Grantham; David E Kandzari; Nicholas Lembo; Jeffrey W Moses; Ajay J Kirtane; Manish Parikh; Philip Green; Matthew Finn; Santiago Garcia; Anthony H Doing; Raja Hatem; Craig A Thompson; Subhash Banerjee; Emmanouil S Brilakis Journal: Can J Cardiol Date: 2016-11-11 Impact factor: 5.223
Authors: Felix Preisser; Elio Mazzone; Sophie Knipper; Sebastiano Nazzani; Marco Bandini; Shahrokh F Shariat; Michele Marchioni; Zhe Tian; Fred Saad; Daniel Taussky; Alberto Briganti; Hartwig Huland; Markus Graefen; Derya Tilki; Pierre I Karakiewicz Journal: Can Urol Assoc J Date: 2019-11-29 Impact factor: 1.862