BACKGROUND/AIM: CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. MATERIALS AND METHODS: We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined. RESULTS: CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells. CONCLUSION: CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy. Copyright
BACKGROUND/AIM: CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. MATERIALS AND METHODS: We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined. RESULTS:CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. TumorCD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells. CONCLUSION:CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy. Copyright
Authors: Millena Prata Jammal; Márcia Antoniazi Michelin; Rosekeila Simões Nomelini; Eddie Fernando Candido Murta Journal: Ann Transl Med Date: 2018-09
Authors: Kyle Hansen; Sandeep Kumar; Kathryn Logronio; Sarah Whelan; Samir Qurashi; Hsin-Yuan Cheng; Andrew Drake; Margaret Tang; Patrick Wall; David Bernados; Ling Leung; Eran Ophir; Zoya Alteber; Gady Cojocaru; Moran Galperin; Masha Frenkel; Mark White; John Hunter; Spencer C Liang; Maya F Kotturi Journal: Cancer Immunol Immunother Date: 2021-04-26 Impact factor: 6.968