Suvi Sirkku Tuohinen1, Tanja Skyttä2, Vesa Virtanen3, Tiina Luukkaala4, Pirkko-Liisa Kellokumpu-Lehtinen2, Pekka Raatikainen5. 1. Heart Center Co., Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland suvi.tuohinen@sydansairaala.fi. 2. Department of Oncology, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland. 3. Heart Center Co., Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland. 4. Science Center Pirkanmaa Hospital District and School of Health Sciences, University of Tampere, Tampere, Finland. 5. Department of Medicine, Central Finland Health Care District and University of Eastern Finland, Jyväskylä, Finland.
Abstract
AIM: Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. PATIENTS AND METHODS: Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis. RESULTS: Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p<0.001), S' from 12.7 ± 3.1 m/s to 12.2 ± 2.7 m/s (p=0.11) and pulmonary flow velocity time integral (VTI) from 16.6 ± 3.1 cm to 15.9 ± 2.3 cm (p=0.07), respectively. These changes were unrelated to changes in LV function. CONCLUSION: Modern radiotherapy reduced RV systolic function. As a readily-available and sensitive measurement, TAPSE is as a practical tool for detection of radiotherapy-induced cardiac changes. Copyright
AIM: Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. PATIENTS AND METHODS: Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis. RESULTS: Radiotherapy reduced TAPSE from 24.5 ± 4.0 mm to 22.4 ± 3.9 mm (p<0.001), S' from 12.7 ± 3.1 m/s to 12.2 ± 2.7 m/s (p=0.11) and pulmonary flow velocity time integral (VTI) from 16.6 ± 3.1 cm to 15.9 ± 2.3 cm (p=0.07), respectively. These changes were unrelated to changes in LV function. CONCLUSION: Modern radiotherapy reduced RV systolic function. As a readily-available and sensitive measurement, TAPSE is as a practical tool for detection of radiotherapy-induced cardiac changes. Copyright
Authors: Suvi Sirkku Tuohinen; Tanja Skyttä; Vesa Virtanen; Marko Virtanen; Tiina Luukkaala; Pirkko-Liisa Kellokumpu-Lehtinen; Pekka Raatikainen Journal: Int J Cardiovasc Imaging Date: 2016-01-12 Impact factor: 2.357
Authors: Robert W Mutter; J Isabelle Choi; Rachel B Jimenez; Youlia M Kirova; Marcio Fagundes; Bruce G Haffty; Richard A Amos; Julie A Bradley; Peter Y Chen; Xuanfeng Ding; Antoinette M Carr; Leslie M Taylor; Mark Pankuch; Raymond B Mailhot Vega; Alice Y Ho; Petra Witt Nyström; Lisa A McGee; James J Urbanic; Oren Cahlon; John H Maduro; Shannon M MacDonald Journal: Int J Radiat Oncol Biol Phys Date: 2021-05-25 Impact factor: 8.013
Authors: Hanna Aula; Tanja Skyttä; Suvi Tuohinen; Tiina Luukkaala; Mari Hämäläinen; Vesa Virtanen; Pekka Raatikainen; Eeva Moilanen; Pirkko-Liisa Kellokumpu-Lehtinen Journal: Breast Date: 2019-12-06 Impact factor: 4.380
Authors: Hanna Aula; Tanja Skyttä; Suvi Tuohinen; Tiina Luukkaala; Mari Hämäläinen; Vesa Virtanen; Pekka Raatikainen; Eeva Moilanen; Pirkko-Liisa Kellokumpu-Lehtinen Journal: Radiat Oncol Date: 2018-10-19 Impact factor: 3.481
Authors: Valentin Walker; Anne Crijns; Johannes Langendijk; Daan Spoor; Rozemarijn Vliegenthart; Stephanie E Combs; Michael Mayinger; Arantxa Eraso; Ferran Guedea; Manuela Fiuza; Susana Constantino; Radia Tamarat; Dominique Laurier; Jean Ferrières; Elie Mousseaux; Elisabeth Cardis; Sophie Jacob Journal: JMIR Res Protoc Date: 2018-10-01