Oriana Simonetti1, Guendalina Lucarini2, Corrado Rubini3, Raffaella Lazzarini2, Roberto DI Primio2, Annamaria Offidani4. 1. Department of Clinic and Molecular Sciences-Dermatology, Polytechnic University of Marche, Ancona, Italy o.simonetti@univpm.it. 2. Department of Clinic and Molecular Sciences-Histology, Polytechnic University of Marche, Ancona, Italy. 3. Department of Biomedical Sciences and Public Health-Pathological Anatomy and Histopathology, Polytechnic University of Marche, Ancona, Italy. 4. Department of Clinic and Molecular Sciences-Dermatology, Polytechnic University of Marche, Ancona, Italy.
Abstract
AIM: To investigate survivin, AKT and VEGF expression in primary mucosal oral melanoma and explore their correlation with clinicopathological features and prognosis. PATIENTS AND METHODS: Twenty malignant primary oral melanomas were immunostained with antibodies against survivin, AKT, VEGF, CD34. Histological parameters and disease-specific survival were related to marker expressions. RESULTS: Survivin localization was both nuclear and cytoplasmic with a higher expression of nuclear survivin. High melanocyte survivin expression significantly correlated with higher thickness of primary melanoma. A significant positive correlation was found between melanocyte survivin and phospho Akt and VEGF expression. Survivin was significantly associated with the presence of metastasis. High melanocyte survivin and high endothelial VEGF expression were inversely correlated to both overall and disease-specific 5-year survival. CONCLUSION: Survivin, via AKT and VEGF, seems to play an important role in oral melanoma and could represent an important prognostic marker of melanoma progression. Copyright
AIM: To investigate survivin, AKT and VEGF expression in primary mucosal oral melanoma and explore their correlation with clinicopathological features and prognosis. PATIENTS AND METHODS: Twenty malignant primary oral melanomas were immunostained with antibodies against survivin, AKT, VEGF, CD34. Histological parameters and disease-specific survival were related to marker expressions. RESULTS: Survivin localization was both nuclear and cytoplasmic with a higher expression of nuclear survivin. High melanocyte survivin expression significantly correlated with higher thickness of primary melanoma. A significant positive correlation was found between melanocyte survivin and phospho Akt and VEGF expression. Survivin was significantly associated with the presence of metastasis. High melanocyte survivin and high endothelial VEGF expression were inversely correlated to both overall and disease-specific 5-year survival. CONCLUSION: Survivin, via AKT and VEGF, seems to play an important role in oral melanoma and could represent an important prognostic marker of melanoma progression. Copyright
Authors: Zakir Khan; Abdul Arif Khan; Hariom Yadav; Godavarthi B K S Prasad; Prakash Singh Bisen Journal: Cell Mol Biol Lett Date: 2017-04-05 Impact factor: 5.787
Authors: Xinan Sheng; Xieqiao Yan; Zhihong Chi; Lu Si; Chuanliang Cui; Bixia Tang; Siming Li; Lili Mao; Bin Lian; Xuan Wang; Xue Bai; Li Zhou; Yan Kong; Jie Dai; Kai Wang; Xiongwen Tang; Huaning Zhou; Hai Wu; Hui Feng; Sheng Yao; Keith T Flaherty; Jun Guo Journal: J Clin Oncol Date: 2019-08-12 Impact factor: 44.544