Lauri Jouhi1, Virve Koljonen2, Tom Böhling3, Caj Haglund4, Jaana Hagström5. 1. Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland. 2. Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland virve.koljonen@hus.fi. 3. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 4. Department of Intestinal Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland. 5. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Department of Oral Pathology, University of Helsinki, Helsinki, Finland.
Abstract
AIM: We sought to clarify whether the expression of toll-like receptors (TLR) in Merkel cell carcinoma (MCC) is linked to tumor and patient characteristics, especially the presence of Merkel cell polyoma virus (MCV). MATERIALS AND METHODS: The study comprised of 128 patients with data on Merkel cell polyomavirus (MCV) status and clinical features were included in the study. Immunohistochemistry for TLR expression was performed on tissue microarray (TMA) slides. RESULTS: TLR 2, 4, 5, 7 and 9 expression was noted in most of the tumor specimens. Decreased expression of TLR 9 correlated strongly with MCV positivity. Cytoplasmic TLR 2 expression correlated with small tumor size, while nuclear TLR 2 and TLR 5 expressions with larger tumors. Increased nuclear TLR 4 expression and decreased TLR 7 expression were associated with older age. CONCLUSION: TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and prognostic markers of MCC tumors. Copyright
AIM: We sought to clarify whether the expression of toll-like receptors (TLR) in Merkel cell carcinoma (MCC) is linked to tumor and patient characteristics, especially the presence of Merkel cell polyoma virus (MCV). MATERIALS AND METHODS: The study comprised of 128 patients with data on Merkel cell polyomavirus (MCV) status and clinical features were included in the study. Immunohistochemistry for TLR expression was performed on tissue microarray (TMA) slides. RESULTS:TLR 2, 4, 5, 7 and 9 expression was noted in most of the tumor specimens. Decreased expression of TLR 9 correlated strongly with MCV positivity. Cytoplasmic TLR 2 expression correlated with small tumor size, while nuclear TLR 2 and TLR 5 expressions with larger tumors. Increased nuclear TLR 4 expression and decreased TLR 7 expression were associated with older age. CONCLUSION:TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and prognostic markers of MCC tumors. Copyright
Authors: Chen Shuang; Yuan Weiguang; Fu Zhenkun; Huang Yike; Yang Jiankun; Xue Jing; Liu Xinghan; Li Yue; Li Dalin Journal: Oncotarget Date: 2017-08-14
Authors: Karolina Stachyra; Monika Dudzisz-Śledź; Elżbieta Bylina; Anna Szumera-Ciećkiewicz; Mateusz J Spałek; Ewa Bartnik; Piotr Rutkowski; Anna M Czarnecka Journal: Int J Mol Sci Date: 2021-06-11 Impact factor: 5.923