Barbara Goeggel Simonetti1, Ariane Cavelti1, Marcel Arnold1, Sandra Bigi1, Mária Regényi1, Heinrich P Mattle1, Jan Gralla1, Joel Fluss1, Peter Weber1, Annette Hackenberg1, Maja Steinlin2, Urs Fischer1. 1. From the Division of Pediatric Neurology (B.G.S., S.B., M.R., M.S.), University Children's Hospital, Inselspital, and University of Bern; Departments of Neurology (B.G.S., A.C., M.A., H.P.M., U.F.) and Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University Hospital Bern, and University of Bern; Division of Pediatric Neurology (J.F.), University Hospital Geneva; Division of Pediatric Neurology (P.W.), University Children's Hospital Basel; and Division of Pediatric Neurology (A.H.), University Children's Hospital Zurich, Switzerland. 2. From the Division of Pediatric Neurology (B.G.S., S.B., M.R., M.S.), University Children's Hospital, Inselspital, and University of Bern; Departments of Neurology (B.G.S., A.C., M.A., H.P.M., U.F.) and Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University Hospital Bern, and University of Bern; Division of Pediatric Neurology (J.F.), University Hospital Geneva; Division of Pediatric Neurology (P.W.), University Children's Hospital Basel; and Division of Pediatric Neurology (A.H.), University Children's Hospital Zurich, Switzerland. maja.steinlin@insel.ch.
Abstract
OBJECTIVE: To compare long-term outcome of children and young adults with arterial ischemic stroke (AIS) from 2 large registries. METHODS: Prospective cohort study comparing functional and psychosocial long-term outcome (≥2 years after AIS) in patients who had AIS during childhood (1 month-16 years) or young adulthood (16.1-45 years) between January 2000 and December 2008, who consented to follow-up. Data of children were collected prospectively in the Swiss Neuropediatric Stroke Registry, young adults in the Bernese stroke database. RESULTS: Follow-up information was available in 95/116 children and 154/187 young adults. Median follow-up of survivors was 6.9 years (interquartile range 4.7-9.4) and did not differ between the groups (p = 0.122). Long-term functional outcome was similar (p = 0.896): 53 (56%) children and 84 (55%) young adults had a favorable outcome (modified Rankin Scale 0-1). Mortality in children was 14% (13/95) and in young adults 7% (11/154) (p = 0.121) and recurrence rate did not differ (p = 0.759). Overall psychosocial impairment and quality of life did not differ, except for more behavioral problems among children (13% vs 5%, p = 0.040) and more frequent reports of an impact of AIS on everyday life among adults (27% vs 64%, p < 0.001). In a multivariate regression analysis, low Pediatric NIH Stroke Scale/NIH Stroke Scale score was the most important predictor of favorable outcome (p < 0.001). CONCLUSION: There were no major differences in long-term outcome after AIS in children and young adults for mortality, disability, quality of life, psychological, or social variables.
OBJECTIVE: To compare long-term outcome of children and young adults with arterial ischemic stroke (AIS) from 2 large registries. METHODS: Prospective cohort study comparing functional and psychosocial long-term outcome (≥2 years after AIS) in patients who had AIS during childhood (1 month-16 years) or young adulthood (16.1-45 years) between January 2000 and December 2008, who consented to follow-up. Data of children were collected prospectively in the Swiss Neuropediatric Stroke Registry, young adults in the Bernese stroke database. RESULTS: Follow-up information was available in 95/116 children and 154/187 young adults. Median follow-up of survivors was 6.9 years (interquartile range 4.7-9.4) and did not differ between the groups (p = 0.122). Long-term functional outcome was similar (p = 0.896): 53 (56%) children and 84 (55%) young adults had a favorable outcome (modified Rankin Scale 0-1). Mortality in children was 14% (13/95) and in young adults 7% (11/154) (p = 0.121) and recurrence rate did not differ (p = 0.759). Overall psychosocial impairment and quality of life did not differ, except for more behavioral problems among children (13% vs 5%, p = 0.040) and more frequent reports of an impact of AIS on everyday life among adults (27% vs 64%, p < 0.001). In a multivariate regression analysis, low Pediatric NIH Stroke Scale/NIH Stroke Scale score was the most important predictor of favorable outcome (p < 0.001). CONCLUSION: There were no major differences in long-term outcome after AIS in children and young adults for mortality, disability, quality of life, psychological, or social variables.
Authors: Peter B Sporns; Ronald Sträter; Jens Minnerup; Heinz Wiendl; Uta Hanning; René Chapot; Hans Henkes; Elina Henkes; Astrid Grams; Franziska Dorn; Omid Nikoubashman; Martin Wiesmann; Georg Bier; Anushe Weber; Gabriel Broocks; Jens Fiehler; Alex Brehm; Marios Psychogios; Daniel Kaiser; Umut Yilmaz; Andrea Morotti; Wolfgang Marik; Richard Nolz; Ulf Jensen-Kondering; Bernd Schmitz; Stefan Schob; Oliver Beuing; Friedrich Götz; Johannes Trenkler; Bernd Turowski; Markus Möhlenbruch; Christina Wendl; Peter Schramm; Patricia Musolino; Sarah Lee; Marc Schlamann; Alexander Radbruch; Nicole Rübsamen; André Karch; Walter Heindel; Moritz Wildgruber; André Kemmling Journal: JAMA Neurol Date: 2020-01-01 Impact factor: 18.302
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Authors: Shehu U Abdullahi; Michael R DeBaun; Lori C Jordan; Mark Rodeghier; Najibah A Galadanci Journal: Pediatr Neurol Date: 2019-01-17 Impact factor: 3.372