Fahad Al-Hameed1, Ali S Wahla2, Shakeel Siddiqui3, Alaa Ghabashi4, Majid Al-Shomrani5, Abdulhakeem Al-Thaqafi5, Yasir Tashkandi4. 1. Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia These authors contributed equally to the work and are co-authors. 2. Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia These authors contributed equally to the work and are co-authors. aliwahla@hotmail.com. 3. Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia. 4. Department of Intensive Care, King Abdul-Aziz Medical City (KAMC-WR), National Guard Health Affairs, Jeddah, Saudi Arabia King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia. 5. King Saud bin Abdul-Aziz University for Health sciences (KSAU-HS), Jeddah, Saudi Arabia Department of Infection Prevention and Control, King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
Abstract
BACKGROUND: An increasing number of patients are being infected with Middle East respiratory syndrome coronavirus (MERS-CoV) since the first case was identified in September 2012. We report the characteristics and outcomes of MERS-CoV-confirmed patients who developed critical illness requiring admission to an intensive care unit (ICU). METHODS: We conducted a prospective cohort study of all MERS-CoV-confirmed cases who were admitted to our ICU from March 20, 2014, till June 1, 2014. Presenting symptoms, comorbid conditions, and details of their ICU stay were recorded. RESULTS: Eight patients were admitted to the ICU with MERS-CoV infection. All had signs of respiratory distress with 7 requiring mechanical ventilation. Three patients were health care workers. In all, 6 patients had comorbid conditions and 5 patients developed multiorgan system failure (MOSF). In all, 5 patients expired, 2 were discharged alive, and 1 remained intubated at the end of the study period. CONCLUSIONS: Middle East respiratory syndrome coronavirus carries a high mortality rate in patients who require ICU admission, with a significant number of patients developing MOSF. Further investigation is needed to determine optimal management guidelines for these patients.
BACKGROUND: An increasing number of patients are being infected with Middle East respiratory syndrome coronavirus (MERS-CoV) since the first case was identified in September 2012. We report the characteristics and outcomes of MERS-CoV-confirmed patients who developed critical illness requiring admission to an intensive care unit (ICU). METHODS: We conducted a prospective cohort study of all MERS-CoV-confirmed cases who were admitted to our ICU from March 20, 2014, till June 1, 2014. Presenting symptoms, comorbid conditions, and details of their ICU stay were recorded. RESULTS: Eight patients were admitted to the ICU with MERS-CoV infection. All had signs of respiratory distress with 7 requiring mechanical ventilation. Three patients were health care workers. In all, 6 patients had comorbid conditions and 5 patients developed multiorgan system failure (MOSF). In all, 5 patients expired, 2 were discharged alive, and 1 remained intubated at the end of the study period. CONCLUSIONS:Middle East respiratory syndrome coronavirus carries a high mortality rate in patients who require ICU admission, with a significant number of patients developing MOSF. Further investigation is needed to determine optimal management guidelines for these patients.
Authors: Ghaleb A Almekhlafi; Mohammed M Albarrak; Yasser Mandourah; Sahar Hassan; Abid Alwan; Abdullah Abudayah; Sultan Altayyar; Mohamed Mustafa; Tareef Aldaghestani; Adnan Alghamedi; Ali Talag; Muhammad K Malik; Ali S Omrani; Yasser Sakr Journal: Crit Care Date: 2016-05-07 Impact factor: 9.097
Authors: Kun Li; Christine Wohlford-Lenane; Stanley Perlman; Jincun Zhao; Alexander K Jewell; Leah R Reznikov; Katherine N Gibson-Corley; David K Meyerholz; Paul B McCray Journal: J Infect Dis Date: 2015-10-20 Impact factor: 5.226