Michael Bauer1, Tasha Glenn2, Martin Alda3, Ole A Andreassen4, Elias Angelopoulos5, Raffaella Ardau6, Christopher Baethge7, Rita Bauer8, Bernhard T Baune9, Frank Bellivier10, Robert H Belmaker11, Michael Berk12, Thomas D Bjella4, Letizia Bossini13, Yuly Bersudsky11, Eric Yat Wo Cheung14, Jörn Conell8, Maria Del Zompo15, Seetal Dodd16, Bruno Etain17, Andrea Fagiolini13, Mark A Frye18, Kostas N Fountoulakis19, Jade Garneau-Fournier20, Ana Gonzalez-Pinto21, John F Gottlieb22, Hirohiko Harima23, Stefanie Hassel24, Chantal Henry17, Apostolos Iacovides19, Erkki T Isometsä25, Flávio Kapczinski26, Sebastian Kliwicki27, Barbara König28, Rikke Krogh29, Mauricio Kunz26, Beny Lafer30, Erik R Larsen29, Ute Lewitzka8, Carlos Lopez-Jaramillo31, Glenda MacQueen24, Mirko Manchia3, Wendy Marsh32, Mónica Martinez-Cengotitabengoa21, Ingrid Melle4, Scott Monteith33, Gunnar Morken34, Rodrigo Munoz35, Fabiano G Nery30, Claire O'Donovan3, Yamima Osher11, Andrea Pfennig8, Danilo Quiroz36, Raj Ramesar37, Natalie Rasgon20, Andreas Reif38, Philipp Ritter8, Janusz K Rybakowski27, Kemal Sagduyu39, Ângela Miranda-Scippa40, Emanuel Severus8, Christian Simhandl28, Dan J Stein41, Sergio Strejilevich42, Ahmad Hatim Sulaiman43, Kirsi Suominen44, Hiromi Tagata23, Yoshitaka Tatebayashi45, Carla Torrent46, Eduard Vieta46, Biju Viswanath47, Mihir J Wanchoo18, Mark Zetin48, Peter C Whybrow49. 1. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany. Electronic address: michael.bauer@uniklinikum-dresden.de. 2. ChronoRecord Association, Fullerton, CA, USA. 3. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. 4. NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, Oslo, Norway. 5. Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece. 6. Unit of Clinical Pharmacology, University-Hospital of Cagliari, Italy. 7. Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany. 8. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany. 9. Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia. 10. Psychiatrie, GH Saint-Louis - Lariboisière - F. Widal, AP-HP, INSERM UMR-S1144, Faculté de Médecine, Université D. Diderot, Paris, France; Fondation FondaMental, Créteil, France. 11. Department of Psychiatry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva Mental Health Center, Beer Sheva, Israel. 12. IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria 3220, Australia; Department of Psychiatry, ORYGEN Youth Health Research Centre, Centre for Youth Mental Health and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia. 13. Department of Molecular Medicine and Department of Mental Health (DAI), University of Siena and University of Siena Medical Center (AOUS), Siena, Italy. 14. Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong. 15. Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Sardinia, Italy. 16. IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria 3220, Australia; Department of Psychiatry, University of Melbourne, Parkville, Victoria 3052, Australia. 17. AP-HP, Hôpitaux Universitaires Henri-Mondor, INSERM U955 (IMRB), Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France. 18. Department of Psychiatry & Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, USA. 19. 3rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. 20. Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Palo Alto, CA, USA. 21. Department of Psychiatry, University Hospital of Alava, University of the Basque Country, CIBERSAM, Vitoria, Spain. 22. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 23. Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan. 24. Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, AB, Canada. 25. Department of Psychiatry, Institute of Clinical Medicine, University of Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland. 26. Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 27. Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. 28. BIPOLAR Zentrum Wiener Neustadt, Wiener Neustadt, Austria. 29. Department of Affective Disorders, Q, Mood Disorders Research Unit, Aarhus University Hospital, Denmark. 30. Bipolar Disorder Research Program, Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. 31. Mood Disorders Program, Fundacion San Vicente de Paul, Department of Psychiatry, Universidad de Antioquia, Medellín, Colombia. 32. Department of Psychiatry, University of Massachusetts, Worcester, MA, USA. 33. Michigan State University College of Human Medicine, Traverse City Campus, Traverse City, MI, USA. 34. Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Research and Development, Psychiatry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 35. Department of Psychiatry, University of California San Diego, San Diego, CA, USA. 36. Deparment of Psychiatry, Diego Portales University, Santiago, Chile. 37. UCT/MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. 38. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe-University Frankfurt am Main, Germany. 39. Department of Psychiatry, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA. 40. Department of Neuroscience and Mental Health, Federal University of Bahia, Salvador, Brazil. 41. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. 42. Bipolar Disorder Program, Neuroscience Institute, Favaloro University, Buenos Aires, Argentina. 43. Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 44. City of Helsinki, Department of Social Services and Health Care, Psychiatry, Helsinki, Finland. 45. Schizophrenia & Affective Disorders Research Project, Tokyo Metropolitan Institute of Medical Science, Seatagaya, Tokyo, Japan. 46. Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. 47. Department of Psychiatry, NIMHANS, Bangalore 560029, India. 48. Department of Psychology, Chapman University, Orange, CA, USA. 49. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Abstract
BACKGROUND: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. METHODS: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 41.3 S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. RESULTS: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. CONCLUSIONS: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.
BACKGROUND: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. METHODS: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 41.3 S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. RESULTS: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. CONCLUSIONS: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.
Authors: Ariadna Besga; Itxaso Gonzalez; Enrique Echeburua; Alexandre Savio; Borja Ayerdi; Darya Chyzhyk; Jose L M Madrigal; Juan C Leza; Manuel Graña; Ana Maria Gonzalez-Pinto Journal: Front Aging Neurosci Date: 2015-12-14 Impact factor: 5.750
Authors: B Etain; M Lajnef; A Henrion; A A Dargél; L Stertz; F Kapczinski; F Mathieu; C Henry; S Gard; J P Kahn; M Leboyer; S Jamain; F Bellivier Journal: Sci Rep Date: 2015-11-06 Impact factor: 4.379