Literature DB >> 25862286

Studying tauopathies in Drosophila: A fruitful model.

Mingkuan Sun1, Liam Chen2.   

Abstract

Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the presence of abnormally phosphorylated tau aggregates. In this review, we will summarize key features of transgenic Drosophila models of tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Drosophila; Frontotemporal dementia; Tau; Tauopathy

Mesh：

Substances：

Year:  2015        PMID： 25862286     DOI： 10.1016/j.expneurol.2015.03.029

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  8 in total

1.  FTD-associated mutations in Tau result in a combination of dominant and recessive phenotypes.

Authors:  Alexander D Law; Marlène Cassar; Dani M Long; Eileen S Chow; Jadwiga M Giebultowicz; Anjana Venkataramanan; Roland Strauss; Doris Kretzschmar
Journal:  Neurobiol Dis       Date:  2022-05-16       Impact factor: 7.046

2.  Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.

Authors:  Soram Idiyasan Chanu; Surajit Sarkar
Journal:  Mol Neurobiol       Date:  2016-03-21       Impact factor: 5.590

Review 3.  Social modulation of ageing: mechanisms, ecology, evolution.

Authors:  Tyler P Quigley; Gro V Amdam
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2021-03-08       Impact factor: 6.237

Review 4.  Tau physiology and pathomechanisms in frontotemporal lobar degeneration.

Authors:  Liviu-Gabriel Bodea; Anne Eckert; Lars Matthias Ittner; Olivier Piguet; Jürgen Götz
Journal:  J Neurochem       Date:  2016-06-15       Impact factor: 5.372

5.  Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons.

Authors:  Josefin Fernius; Annika Starkenberg; Stefan Thor
Journal:  Dis Model Mech       Date:  2017-06-14       Impact factor: 5.758

6.  Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau.

Authors:  Josefin Fernius; Annika Starkenberg; Malgorzata Pokrzywa; Stefan Thor
Journal:  Biol Open       Date:  2017-07-15       Impact factor: 2.422

7.  What triggers tauopathy in chronic traumatic encephalopathy?

Authors:  Liam Chen
Journal:  Neural Regen Res       Date:  2018-06       Impact factor: 5.135

8.  Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities.

Authors:  Shuke Nie; Yang Tan; Zhentao Zhang; Guiqin Chen; Jing Xiong; Dan Hu; Keqiang Ye; Yunjian Zhang; Xuebing Cao; Liam Chen; Zhaohui Zhang
Journal:  Front Aging Neurosci       Date:  2018-10-04       Impact factor: 5.750
  8 in total

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