Literature DB >> 2586115

An improved method to correct the QT interval of the electrocardiogram for changes in heart rate.

A Van de Water1, J Verheyen, R Xhonneux, R S Reneman.   

Abstract

The adequacy of the Bazett formula to correct for heart rate-induced changes in the QT interval of the electrocardiogram has been frequently questioned. In the present study, a simple linear equation was derived, which in anesthetized dogs corrects more adequately for changes in heart rate than the Bazett formula. Regression analysis of experimental data yielded the following equation: QTc = QT - 0.087 (RR - 1000) = QT - 87 (60/HR - 1). The reliability of this equation was investigated in experiments on anesthetized dogs with different cardioactive drugs with a known mechanism of action.

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Year:  1989        PMID： 2586115     DOI： 10.1016/0160-5402(89)90015-6

Source DB:  PubMed          Journal:  J Pharmacol Methods        ISSN： 0160-5402


  53 in total

1.  Na+-K+ pump inhibition caused by chronic amiodarone in guinea pig myocardium.

Authors:  T Maruyama; N Ueda; Y Kaji; S Kanaya; T Fujino; Y Niho
Journal:  Heart Vessels       Date:  1999       Impact factor: 2.037

2.  Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.

Authors:  Herbert M Himmel; Alexandra Bussek; Michael Hoffmann; Rolf Beckmann; Horst Lohmann; Matthias Schmidt; Erich Wettwer
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

3.  Orally administered moxifloxacin prolongs QTc in healthy Chinese volunteers: a randomized, single-blind, crossover study.

Authors:  Qian Chen; Yan-mei Liu; Yun Liu; Boaz Mendzelevski; Dennis Chanter; Hua-hua Pu; Gang-yi Liu; Onglee Weng; Chao-ying Hu; Wei Wang; Chen Yu; Jing-ying Jia
Journal:  Acta Pharmacol Sin       Date:  2015-03-23       Impact factor: 6.150

4.  Comparison of formulas for calculation of the corrected QT interval in infants and young children.

Authors:  Derek Q Phan; Michael J Silka; Yueh-Tze Lan; Ruey-Kang R Chang
Journal:  J Pediatr       Date:  2015-01-31       Impact factor: 4.406

5.  Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs.

Authors:  Nathan M Appel; Shou-Hua Li; Tyson H Holmes; Jane B Acri
Journal:  J Pharmacol Exp Ther       Date:  2015-07-15       Impact factor: 4.030

6.  The ways and means of correcting the QT interval.

Authors:  R Abdulla
Journal:  Pediatr Cardiol       Date:  1997 Jan-Feb       Impact factor: 1.655

7.  The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias.

Authors:  H J van der Linde; B Van Deuren; Y Somers; B Loenders; R Towart; D J Gallacher
Journal:  Br J Pharmacol       Date:  2010-12       Impact factor: 8.739

Review 8.  Drug-induced torsades de pointes and implications for drug development.

Authors:  Robert R Fenichel; Marek Malik; Charles Antzelevitch; Michael Sanguinetti; Dan M Roden; Silvia G Priori; Jeremy N Ruskin; Raymond J Lipicky; Louis R Cantilena
Journal:  J Cardiovasc Electrophysiol       Date:  2004-04

9.  Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies.

Authors:  S Cora Verduyn; Jérôme G M Jungschleger; Milan Stengl; Roel L H M G Spätjens; Jet D M Beekman; Marc A Vos
Journal:  Pflugers Arch       Date:  2004-10       Impact factor: 3.657

10.  Effect of selection of QTc formula on eligibility of cancer patients for phase I clinical trials.

Authors:  Mitesh J Borad; Arundhati D Soman; Martin Benjamin; Daniel Casa; Waibhav D Tembe; Barbara F Piper; Ramesh Ramanathan; Raoul Tibes; Gayle Jameson; Karen Ansaldo; Daniel D Von Hoff
Journal:  Invest New Drugs       Date:  2012-12-16       Impact factor: 3.850
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