Hasan Altinkaynak1, Erdinç Ceylan2, Baki Kartal2, Sadullah Keleş3, Metin Ekinci4, Osman Okan Olcaysu2. 1. a Department of Ophthalmology , Ankara Ataturk Education and Research Hospital , Ankara , Turkey . 2. b Department of Ophthalmology , Erzurum Regional Education and Research Hospital , Erzurum , Turkey . 3. c Department of Ophthalmology , Ataturk University , Erzurum , Turkey , and. 4. d Department of Ophthalmology , Kafkas University , Kars , Turkey.
Abstract
PURPOSE: The aim of this study is to investigate the effect of 200 mg caffeine on subfoveal choroidal thickness (CT) in the macular area as measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in healthy subjects. MATERIALS AND METHODS: Fifty healthy individuals (study group) and 50 healthy individuals (control group) were enrolled in study. In the study group, participants received a 200 mg caffeine capsule and the control group consisted of subjects who received plasebo capsule. The subfoveal CT was measured by EDI-OCT before the caffeine intake and at 30 min, 1 h, 2 h, 3 h, 4 h and 6 h following caffeine intake. RESULTS: SFCT after caffeine intake was significantly decreased at 30 min, 1 h, 2 h, 3 h and 4 h compared to the baseline measurement, while the difference between baseline and 6 h was not statistically significant in the study group. There were no significant differences between the baseline and the other measurement times in the control group (p > 0.05). CONCLUSION: The thinning of CT begins about 30 min after the oral ingestion of 200 mg of caffeine and lasts for about four hours.
PURPOSE: The aim of this study is to investigate the effect of 200 mg caffeine on subfoveal choroidal thickness (CT) in the macular area as measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in healthy subjects. MATERIALS AND METHODS: Fifty healthy individuals (study group) and 50 healthy individuals (control group) were enrolled in study. In the study group, participants received a 200 mg caffeine capsule and the control group consisted of subjects who received plasebo capsule. The subfoveal CT was measured by EDI-OCT before the caffeine intake and at 30 min, 1 h, 2 h, 3 h, 4 h and 6 h following caffeine intake. RESULTS: SFCT after caffeine intake was significantly decreased at 30 min, 1 h, 2 h, 3 h and 4 h compared to the baseline measurement, while the difference between baseline and 6 h was not statistically significant in the study group. There were no significant differences between the baseline and the other measurement times in the control group (p > 0.05). CONCLUSION: The thinning of CT begins about 30 min after the oral ingestion of 200 mg of caffeine and lasts for about four hours.