| Literature DB >> 25860635 |
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Abstract
Entities:
Year: 2015 PMID: 25860635 PMCID: PMC4393314 DOI: 10.1371/journal.pgen.1005126
Source DB: PubMed Journal: PLoS Genet ISSN: 1553-7390 Impact factor: 5.917
Fig 1Melanism mutations and phenotypes in three Leopardus species.
(A) Color phenotypes of the pampas cat (L. colocolo), Geoffroy’s cat (L. geoffroyi), and kodkod (L. guigna). Tabby markings in the non-melanistic (NM) forms shown here are obscured in the melanistic (M) forms. (B) Geographic distribution (modified from [7]); red circles represent the approximate origin of samples as described in the text. Right upper panel indicates phylogenetic relationships and estimated divergence times based on [4] (C, D) Location of missense variants in ASIP (kodkod, pampas cat) and MC1R (Geoffroy’s cat). (C) The kodkod and pampas cat variants are predicted to disrupt the three dimensional structure of a disulfide-stabilized loop in ASIP that is critical for MC1R binding [30]. (D) The Geoffroy’s cat melanism allele carries three missense variants in MC1R; C125R is likely to be causative as described in the text.