Literature DB >> 25860559

Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

R A Hauser-Davis1, L V de Freitas, D S Cukierman, W S Cruz, M C Miotto, J Landeira-Fernandez, A A Valiente-Gabioud, C O Fernández, N A Rey.   

Abstract

Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg(-1), showing potential as an anti-Alzheimer's drug.

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Year:  2015        PMID： 25860559     DOI： 10.1039/c5mt00003c

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  6 in total

1.  Aroylhydrazones constitute a promising class of 'metal-protein attenuating compounds' for the treatment of Alzheimer's disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone.

Authors:  Daphne S Cukierman; Elio Accardo; Rosana Garrido Gomes; Anna De Falco; Marco C Miotto; Maria Clara Ramalho Freitas; Mauricio Lanznaster; Claudio O Fernández; Nicolás A Rey
Journal:  J Biol Inorg Chem       Date:  2018-08-25       Impact factor: 3.358

2.  Tridentate N-Acylhydrazones as Moderate Ligands for the Potential Management of Cognitive Decline Associated With Metal-Enhanced Neuroaggregopathies.

Authors:  Daphne S Cukierman; Nicolás A Rey
Journal:  Front Neurol       Date:  2022-02-16       Impact factor: 4.003

3.  Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease.

Authors:  Frank W Lewis; Kathleen Bird; Jean-Philippe Navarro; Rawa El Fallah; Jeremy Brandel; Véronique Hubscher-Bruder; Andrew Tsatsanis; James A Duce; David Tétard; Samuel Bourne; Mahmoud Maina; Ilse S Pienaar
Journal:  Dalton Trans       Date:  2022-03-01       Impact factor: 4.390

4.  Synthesis, characterization, DFT, antioxidant, antibacterial, pharmacokinetics and inhibition of SARS-CoV-2 main protease of some heterocyclic hydrazones.

Authors:  Lilia Adjissi; Nadjib Chafai; Khalissa Benbouguerra; Imene Kirouani; Abdelkader Hellal; Houdheifa Layaida; Meriem Elkolli; Chawki Bensouici; Salah Chafaa
Journal:  J Mol Struct       Date:  2022-08-23       Impact factor: 3.841

Review 5.  Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.

Authors:  Soghra Bagheri; Rosanna Squitti; Thomas Haertlé; Mariacristina Siotto; Ali A Saboury
Journal:  Front Aging Neurosci       Date:  2018-01-23       Impact factor: 5.750

Review 6.  Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.

Authors:  Hafza Wajeeha Ejaz; Wei Wang; Minglin Lang
Journal:  Int J Mol Sci       Date:  2020-10-16       Impact factor: 5.923
  6 in total

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