BACKGROUND: Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. AIM: To describe the features of GBS in adult Chilean patients admitted to a tertiary care hospital. MATERIAL AND METHODS: Review of medical records of 41 patients aged 17 to 81 years (30 males) admitted to a public hospital with the diagnosis of GBS between 2003 and 2009. According to clinical and electrophysiological criteria, the patients were classified into different varieties of GBS. RESULTS: The incidence of GBS was higher in males (2.7:1) and the demyelinated GBS variety was found in 66% of cases. According to the Hughes disability score, patients treated with plasmapheresis, showed non-statistically significant better outcomes than those treated with intravenous immunoglobulin. CONCLUSIONS: In this group of patients the demyelinated variety of GBS was more common than the axonal type. Although not statistically significant, the better response to plasmapheresis is encouraging and should prompt a controlled study.
BACKGROUND: Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. AIM: To describe the features of GBS in adult Chilean patients admitted to a tertiary care hospital. MATERIAL AND METHODS: Review of medical records of 41 patients aged 17 to 81 years (30 males) admitted to a public hospital with the diagnosis of GBS between 2003 and 2009. According to clinical and electrophysiological criteria, the patients were classified into different varieties of GBS. RESULTS: The incidence of GBS was higher in males (2.7:1) and the demyelinated GBS variety was found in 66% of cases. According to the Hughes disability score, patients treated with plasmapheresis, showed non-statistically significant better outcomes than those treated with intravenous immunoglobulin. CONCLUSIONS: In this group of patients the demyelinated variety of GBS was more common than the axonal type. Although not statistically significant, the better response to plasmapheresis is encouraging and should prompt a controlled study.
Authors: María P Mahecha; Ernesto Ojeda; Daniel A Vega; Juan C Sarmiento-Monroy; Juan-Manuel Anaya Journal: Immunol Res Date: 2017-02 Impact factor: 2.829
Authors: Luíza Morais de Matos; Ariely Teotonio Borges; Aline Barbosa Palmeira; Vinicius Moreira Lima; Ernane Pires Maciel; Rubens Nelson Morato Fernandez; João Pedro Lima Mendes; Gustavo Adolfo Sierra Romero Journal: Rev Soc Bras Med Trop Date: 2022-04-08 Impact factor: 2.141