Vignesh Vikram1, T Ramakrishnan2, K Anilkumar3, N Ambalavanan4. 1. PG Student, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Maduravoyal, Chennai, India . 2. Professor, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Maduravoyal, Chennai, India . 3. Reader, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Maduravoyal, Chennai, India . 4. Professor & HOD, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Maduravoyal, Chennai, India .
Abstract
INTRODUCTION: The aim of the study was to assess changes in Transforming Growth Factor- β1 (TGF-β1) levels in gingival crevicular fluid (GCF) and examine correlation of TGF-β1 levels and periodontal parameters: probing pocket depth (PPD) and clinical attachment level (CAL) in sites with chronic periodontitis at various time intervals before and after periodontal surgery. MATERIALS AND METHODS: The effects of non-surgical and surgical therapy on periodontal parameters and GCF TGF-β1 levels in 18 sites affected with chronic periodontitis were assessed upto 6 weeks post conventional flap surgery. GCF was collected and PPD, CAL recorded at Baseline. GCF was collected and PPD, CAL recorded at Pre-surgery and flap surgery performed. GCF was collected from all sites at Two Weeks Post-surgery. GCF was collected and PPD, CAL recorded at Six Weeks Post-surgery. The concentration of TGF-β1 in GCF was determined using a human TGF-β1 enzyme immunometric assay kit. RESULTS: Mean TGF-β1 concentrations were significantly reduced at Pre-surgery, at Two Weeks Post-surgery and at Six Weeks Post-surgery (p<0.05) when compared to Baseline TGF-β1 values. There was a statistically significant reduction in PPD and gain in CAL following non-surgical and surgical therapy when compared to baseline (p<0.05). CONCLUSION: RESULTS indicate that TGF-β1 may play a role in the pathogenesis and diagnosis of periodontal disease and could be considered as a disease predictive biomarker.
INTRODUCTION: The aim of the study was to assess changes in Transforming Growth Factor- β1 (TGF-β1) levels in gingival crevicular fluid (GCF) and examine correlation of TGF-β1 levels and periodontal parameters: probing pocket depth (PPD) and clinical attachment level (CAL) in sites with chronic periodontitis at various time intervals before and after periodontal surgery. MATERIALS AND METHODS: The effects of non-surgical and surgical therapy on periodontal parameters and GCF TGF-β1 levels in 18 sites affected with chronic periodontitis were assessed upto 6 weeks post conventional flap surgery. GCF was collected and PPD, CAL recorded at Baseline. GCF was collected and PPD, CAL recorded at Pre-surgery and flap surgery performed. GCF was collected from all sites at Two Weeks Post-surgery. GCF was collected and PPD, CAL recorded at Six Weeks Post-surgery. The concentration of TGF-β1 in GCF was determined using a human TGF-β1 enzyme immunometric assay kit. RESULTS: Mean TGF-β1 concentrations were significantly reduced at Pre-surgery, at Two Weeks Post-surgery and at Six Weeks Post-surgery (p<0.05) when compared to Baseline TGF-β1 values. There was a statistically significant reduction in PPD and gain in CAL following non-surgical and surgical therapy when compared to baseline (p<0.05). CONCLUSION: RESULTS indicate that TGF-β1 may play a role in the pathogenesis and diagnosis of periodontal disease and could be considered as a disease predictive biomarker.
Authors: W V Giannobile; S E Lynch; R G Denmark; D W Paquette; J P Fiorellini; R C Williams Journal: J Clin Periodontol Date: 1995-12 Impact factor: 8.728
Authors: Helal F Hetta; Ibrahim M Mwafey; Gaber El-Saber Batiha; Suliman Y Alomar; Nahed A Mohamed; Maggie A Ibrahim; Abeer Elkady; Ahmed Kh Meshaal; Hani Alrefai; Dina M Khodeer; Asmaa M Zahran Journal: Vaccines (Basel) Date: 2020-06-26